Cerebral Cortical Circuitry Formation Requires Functional Glycine Receptors

G Morelli; A Avila; S Ravanidis; N Aourz; R L Neve; I Smolders; Robert J Harvey; J M Rigo; L Nguyen; B Brône

doi:10.1093/cercor/bhw025

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Cerebral Cortical Circuitry Formation Requires Functional Glycine Receptors

Journal article

Peer reviewed

Cerebral Cortical Circuitry Formation Requires Functional Glycine Receptors

G Morelli, A Avila, S Ravanidis, N Aourz, R L Neve, I Smolders, Robert J Harvey, J M Rigo, L Nguyen and B Brône

Cerebral Cortex, Vol.27(3), pp.1863-1877

2017

DOI: https://doi.org/10.1093/cercor/bhw025

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Abstract

cerebral cortex

development

drug-induced epilepsy

glycine receptor

neuronal connectivity

The development of the cerebral cortex is a complex process that requires the generation, migration, and differentiation of neurons. Interfering with any of these steps can impair the establishment of connectivity and, hence, function of the adult brain. Neurotransmitter receptors have emerged as critical players to regulate these biological steps during brain maturation. Among them, α2 subunit-containing glycine receptors (GlyRs) regulate cortical neurogenesis and the present work demonstrates the long-term consequences of their genetic disruption on neuronal connectivity in the postnatal cerebral cortex. Our data indicate that somatosensory cortical neurons of Glra2 knockout mice (Glra2KO) have more dendritic branches with an overall increase in total spine number. These morphological defects correlate with a disruption of the excitation/inhibition balance, thereby increasing network excitability and enhancing susceptibility to epileptic seizures after pentylenetetrazol tail infusion. Taken together, our findings show that the loss of embryonic GlyRα2 ultimately impairs the formation of cortical circuits in the mature brain. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

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Title: Cerebral Cortical Circuitry Formation Requires Functional Glycine Receptors
Authors: G Morelli (Author) - Hasselt University, Belgium
A Avila (Author) - SickKids Research Institute, Canada
S Ravanidis (Author) - Hasselt University, Belgium
N Aourz (Author) - Vrije Universiteit Brussel, Belgium
R L Neve (Author) - Massachusetts Institute of Technology, United States
I Smolders (Author) - Vrije Universiteit Brussel, Belgium
Robert J Harvey (Author) - University College London, United Kingdom
J M Rigo (Author) - Hasselt University, Belgium
L Nguyen (Author) - University of Liège, Belgium
B Brône (Author) - Hasselt University, Belgium
Publication details: Cerebral Cortex, Vol.27(3), pp.1863-1877
Publisher: Oxford University Press
Date published: 2017
DOI: 10.1093/cercor/bhw025
ISSN: 1047-3211
Organisation Unit: School of Health; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99451034602621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Neurosciences

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