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Cerebral Blood Flow during Interval and Continuous Exercise in Young and Old Men
Journal article   Open access   Peer reviewed

Cerebral Blood Flow during Interval and Continuous Exercise in Young and Old Men

Timo Klein, Tom G Bailey, Vera Abeln, Stefan Schneider and Christopher D Askew
Medicine and Science in Sports and Exercise, Vol.51(7), pp.1523-1531
2019
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PDF - Author Accepted Version1.34 MBDownloadView
Accepted VersionPDF - Author Accepted Version Open Access
url
https://doi.org/10.1249/MSS.0000000000001924View
Published Version

Abstract

Purpose: Ageing is associated with impaired cerebral blood flow (CBF) and increased risk of cerebrovascular disease. Acute increases in CBF during exercise may initiate improvements in cerebrovascular health, but the CBF response is diminished during continuous exercise in older adults. The effect of interval exercise for promoting increases in CBF in young and old adults is unknown. Methods: We compared middle cerebral artery blood velocity (MCAv), end-tidal CO2 (PETCO2) and blood pressure (MAP) during intensity- and work-matched bouts of continuous (10-min 60%Wmax, followed by 10-min rest) and interval cycling (10x1-min 60%Wmax, separated by 1-min rest) in 11 young (25±3y) and 10 old (69±3y) men. Results: MCAv was higher during continuous compared with interval exercise in the young (p<0.001), but not in the old. This trend was also seen for changes in PETCO2. While absolute MAP was higher in the old, the relative rise (%[INCREMENT]) in MAP was similar between age groups and was greater during continuous exercise than interval. When we assessed the total accumulated change in MCAv (area under curve: exercise + recovery), it was higher with interval compared with continuous exercise in both groups (p=0.018). Conclusion: These findings suggest that interval exercise may be an effective alternative for promoting acute increases in cerebral blood flow velocity, particularly in those older adults who may have difficulty sustaining continuous exercise.

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