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Published VersionCC BY-NC-ND V4.0, Open Access
Journal article
Central and peripheral scleral lens‐induced corneal oedema
Ophthalmic and Physiological Optics, Vol.44(4), pp.792-800
2024
PMID: 37622425
Abstract
Purpose: To quantify the magnitude of central and peripheral scleral lens-induced corneal oedema for a range of fluid reservoir thicknesses, and to compare these experimental results with theoretical models of corneal oedema both with and without limbal metabolic support (i.e., the lateral transport of metabolites and the influence of the limbal vasculature).
Methods: Ten young healthy participants wore scleral lenses (KATT™, Capricornia Contact Lenses) fitted with low (mean 141 μm), medium (482 μm) and high (718 μm) central fluid reservoir thickness values across three separate study visits. The scleral lens thickness, fluid reservoir thickness and stromal corneal oedema were measured using optical coherence tomography. Oedema was quantified across the central (0-2.5 mm from the corneal apex) and peripheral (1.25-3 mm from the scleral spur) cornea. Experimental data were compared with published theoretical models of central to peripheral corneal oedema.
Results: Stromal oedema varied with fluid reservoir thickness (p < 0.001) for both central and peripheral regions. The mean (standard deviation) stromal oedema was greater for the medium (2.08 (1.21)%) and high (2.22 (1.31)%) fluid reservoir thickness conditions compared to the low condition (1.00 (1.01)%) (p ≤ 0.01). Stromal oedema gradually increased from the corneal centre to the periphery by ~0.3% on average (relative increase of 18%), but the change did not reach statistical significance. This trend of increasing, rather than decreasing, oedema towards the limbus is consistent with theoretical modelling of peripheral oedema without metabolic support from the limbus.
Conclusions: The central and peripheral cornea displayed a similar magnitude of oedema, with increasing levels observed for medium and high fluid reservoir thicknesses. The gradual increase in oedema towards the limbus is consistent with a 'without limbal metabolic support' theoretical model.
Details
- Title
- Central and peripheral scleral lens‐induced corneal oedema
- Authors
- Asif Iqbal (Corresponding Author) - Queensland University of TechnologyDamien Fisher (Author) - Queensland University of TechnologyDavid Alonso-Caneiro (Author) - University of the Sunshine Coast, Queensland, School of Science, Technology and EngineeringMichael J. Collins (Author) - Queensland University of TechnologyStephen J. Vincent (Author) - Queensland University of Technology
- Publication details
- Ophthalmic and Physiological Optics, Vol.44(4), pp.792-800
- Publisher
- Wiley-Blackwell Publishing Ltd.
- Date published
- 2024
- DOI
- 10.1111/opo.13221
- ISSN
- 1475-1313; 0275-5408
- PMID
- 37622425
- Copyright note
- This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. © 2023 The Authors. Ophthalmic and Physiological Optics published by John Wiley & Sons Ltd on behalf of College of Optometrists.
- Grant note
- Queensland University of Technology Cornea and Contact Lens Society of Australia
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 99966895202621
- Output Type
- Journal article
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