Cellular Effects of Pyocyanin, a Secreted Virulence Factor of Pseudomonas aeruginosa

Susan Hall; Catherine McDermott; Shailendra Anoopkumar-Dukie; Amelia J. McFarland; Amanda Forbes; Anthony V. Perkins; Andrew K. Davey; Russ Chess-Williams; Milton J. Kiefel; Devinder Arora; Gary D. Grant

doi:10.3390/toxins8080236

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Cellular Effects of Pyocyanin, a Secreted Virulence Factor of Pseudomonas aeruginosa

Journal article

Open access

Peer reviewed

Cellular Effects of Pyocyanin, a Secreted Virulence Factor of Pseudomonas aeruginosa

Susan Hall, Catherine McDermott, Shailendra Anoopkumar-Dukie, Amelia J. McFarland, Amanda Forbes, Anthony V. Perkins, Andrew K. Davey, Russ Chess-Williams, Milton J. Kiefel, Devinder Arora, …

Toxins, Vol.8, pp.1-14

2016

DOI: https://doi.org/10.3390/toxins8080236

PMCID: PMC4999852

PMID: 27517959

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Abstract

inflammation

oxidative stress

Pseudomonas aeruginosa

pyocyanin

virulence factor

Pyocyanin has recently emerged as an important virulence factor produced by Pseudomonas aeruginosa. The redox-active tricyclic zwitterion has been shown to have a number of potential effects on various organ systems in vitro, including the respiratory, cardiovascular, urological, and central nervous systems. It has been shown that a large number of the effects to these systems are via the formation of reactive oxygen species. The limitations of studies are, to date, focused on the localized effect of the release of pyocyanin (PCN). It has been postulated that, given its chemical properties, PCN is able to readily cross biological membranes, however studies have yet to be undertaken to evaluate this effect. This review highlights the possible manifestations of PCN exposure; however, most studies to date are in vitro. Further high quality in vivo studies are needed to fully assess the physiological manifestations of PCN exposure on the various body systems.

Details

Title: Cellular Effects of Pyocyanin, a Secreted Virulence Factor of Pseudomonas aeruginosa
Authors: Susan Hall (Author) - Griffith University
Catherine McDermott (Author) - Bond University
Shailendra Anoopkumar-Dukie (Author) - Griffith University
Amelia J. McFarland (Author) - Griffith University
Amanda Forbes (Author) - Bond University
Anthony V. Perkins (Author) - Griffith University
Andrew K. Davey (Author) - Griffith University
Russ Chess-Williams (Author) - Bond University
Milton J. Kiefel (Author) - Griffith University
Devinder Arora (Author) - Griffith University
Gary D. Grant (Corresponding Author) - Griffith University
Publication details: Toxins, Vol.8, pp.1-14
Publisher: MDPI AG
Date published: 2016
DOI: 10.3390/toxins8080236
ISSN: 2072-6651
PMID: 27517959; PMC4999852
Copyright note: © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
Organisation Unit: School of Health; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99685194502621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Food Science & Technology; Toxicology

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