Carrageenans from the Red Seaweed Sarconema filiforme Attenuate Symptoms of Diet-Induced Metabolic Syndrome in Rats

Ryan du Preez; Nicholas A Paul; Peter Mouatt; Marwan E Majzoub; Torsten Thomas; Sunil K Panchal; Lindsay Brown

doi:10.3390/md18020097

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Carrageenans from the Red Seaweed Sarconema filiforme Attenuate Symptoms of Diet-Induced Metabolic Syndrome in Rats

Journal article

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Carrageenans from the Red Seaweed Sarconema filiforme Attenuate Symptoms of Diet-Induced Metabolic Syndrome in Rats

Ryan du Preez, Nicholas A Paul, Peter Mouatt, Marwan E Majzoub, Torsten Thomas, Sunil K Panchal and Lindsay Brown

Marine Drugs, Vol.18(2), 97

2020

DOI: https://doi.org/10.3390/md18020097

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Abstract

algae

Sarconema filiforme

sulfated polysaccharides

Î¹-carrageenan

prebiotics

gut microbiota

aquaculture

nutraceutical

Carrageenans are thickening and gelling agents that may provide health benefits. Iota (Î¹)-carrageenan, a linear sulfated polysaccharide, is produced by the red seaweed, Sarconema filiforme. This study investigated the potential of this seaweed as a functional food for the reversal of metabolic syndrome and possible mechanisms. Male Wistar rats were divided into four groups in a 16-week protocol: corn starch diet-fed rats (C); C rats supplemented with 5% S. filiforme for the last 8 weeks (CSF); high-carbohydrate, high-fat diet-fed rats (H); and H rats supplemented with 5% S. filiforme for the last 8 weeks (HSF). S. filiforme was produced in tank-based aquaculture yielding 27 g dry weight/day/m2 of culture area. H rats developed obesity, hypertension, dyslipidaemia, glucose intolerance, fatty liver and increased left ventricular collagen deposition. S. filiforme supplementation decreased body weight, abdominal and liver fat, systolic blood pressure, plasma total cholesterol concentrations, and plasma activities of alanine transaminase and aspartate transaminase. S. filiforme supplementation modulated gut microbiota without changing the Firmicutes to Bacteroidetes ratio. S. filiforme improved symptoms of high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. Possible mechanisms include a reduced infiltration of inflammatory cells into organs as well as prebiotic actions in the gastrointestinal tract.

Details

Title: Carrageenans from the Red Seaweed Sarconema filiforme Attenuate Symptoms of Diet-Induced Metabolic Syndrome in Rats
Authors: Ryan du Preez (Author) - University of Southern Queensland
Nicholas A Paul (Author) - University of the Sunshine Coast - School of Science and Engineering
Peter Mouatt (Author) - Southern Cross University
Marwan E Majzoub (Author) - University of New South Wales
Torsten Thomas (Author) - University of New South Wales
Sunil K Panchal (Author) - University of Southern Queensland
Lindsay Brown (Author) - University of Southern Queensland
Publication details: Marine Drugs, Vol.18(2), 97; 26
Publisher: MDPI AG
Date published: 2020
DOI: 10.3390/md18020097
ISSN: 1660-3397
Copyright note: Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering
Language: English
Record Identifier: 99451419002621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Chemistry, Medicinal; Pharmacology & Pharmacy

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