Journal article
Cardiovascular magnetic resonance of cardiac function and myocardial mass in preterm infants: A preliminary study of the impact of patent ductus arteriosus
Journal of Cardiovascular Magnetic Resonance, Vol.16, 54
2014
Abstract
Background: Many pathologies seen in the preterm population are associated with abnormal blood supply, yet robust evaluation of preterm cardiac function is scarce and consequently normative ranges in this population are limited. The aim of this study was to quantify and validate left ventricular dimension and function in preterm infants using cardiovascular magnetic resonance (CMR). An initial investigation of the impact of the common congenital defect patent ductus arteriosus (PDA) was then carried out. Methods. Steady State Free Procession short axis stacks were acquired. Normative ranges of left ventricular end diastolic volume (EDV), stroke volume (SV), left ventricular output (LVO), ejection fraction (EF), left ventricular (LV) mass, wall thickness and fractional thickening were determined in "healthy" (control) neonates. Left ventricular parameters were then investigated in PDA infants. Unpaired student t-tests compared the 2 groups. Multiple linear regression analysis assessed impact of shunt volume in PDA infants, p-value ≤ 0.05 being significant. Results: 29 control infants median (range) corrected gestational age at scan 34+6(31+1-39+3) weeks were scanned. EDV, SV, LVO, LV mass normalized by weight and EF were shown to decrease with increasing corrected gestational age (cGA) in controls. In 16 PDA infants (cGA 30+3(27+3-36+1) weeks) left ventricular dimension and output were significantly increased, yet there was no significant difference in ejection fraction and fractional thickening between the two groups. A significant association between shunt volume and increased left ventricular mass correcting for postnatal age and corrected gestational age existed. Conclusion: CMR assessment of left ventricular function has been validated in neonates, providing more robust normative ranges of left ventricular dimension and function in this population. Initial investigation of PDA infants would suggest that function is relatively maintained.
Details
- Title
- Cardiovascular magnetic resonance of cardiac function and myocardial mass in preterm infants: A preliminary study of the impact of patent ductus arteriosus
- Authors
- Kathryn Broadhouse (Author) - Imperial College London, United KingdomA E Finnemore (Author) - Imperial College London, United KingdomA N Price (Author) - Imperial College London, United KingdomG Durighel (Author) - Imperial College London, United KingdomD J Cox (Author) - Imperial College London, United KingdomA D Edwards (Author) - Imperial College London, United KingdomJ V Hajnal (Author) - Imperial College London, United KingdomA M Groves (Author) - Imperial College London, United Kingdom
- Publication details
- Journal of Cardiovascular Magnetic Resonance, Vol.16, 54; 9
- Publisher
- BioMed Central Ltd.
- Date published
- 2014
- DOI
- 10.1186/s12968-014-0054-4
- ISSN
- 1097-6647; 1097-6647
- Copyright note
- Copyright © 2014 Broadhouse et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Organisation Unit
- School of Science and Engineering - Legacy; School of Health - Nursing; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
- Language
- English
- Record Identifier
- 99451460402621
- Output Type
- Journal article
Metrics
7 File views/ downloads
156 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Cardiac & Cardiovascular Systems
- Radiology, Nuclear Medicine & Medical Imaging
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites