Cardiostimulant effects of urotensin-II in human heart in vitro

Fraser D Russell; P Molenaar; D O'Brien

doi:10.1038/sj.bjp.0703811

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Cardiostimulant effects of urotensin-II in human heart in vitro

Journal article

Peer reviewed

Cardiostimulant effects of urotensin-II in human heart in vitro

Fraser D Russell, P Molenaar and D O'Brien

British Journal of Pharmacology, Vol.132(1), pp.5-9

2001

DOI: https://doi.org/10.1038/sj.bjp.0703811

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Abstract

Pharmacology and Pharmaceutical Sciences

human urotensin-II

human heart

coronary artery

atrium

ventricle

The effects of the recently identified human peptide urotensin-II (hU-II) were investigated on human cardiac muscle contractility and coronary artery tone. In right atrial trabeculae from non-failing hearts, hU-II caused a concentration-dependent increase in contractile force (pEC50=9.50.1; Emax=31.34.8% compared to 9.25 mM Ca2+; n=9) with no change in contraction duration. In right ventricular trabeculae from explanted hearts, 20 nM hU-II caused a small increase in contractile force (7.81.4% compared to 9.25 mM Ca2+; n=3/6 tissues from 2 out of 4 patients). The peptide caused arrhythmic contractions in 3/26 right atrial trabeculae from 3/9 patients in an experimental model of arrhythmia and therefore has less potential to cause arrhythmias than ET-1. hU-II (20 nM) increased tone (17.9% of the response to 90 mM KCI) in 7/7 tissues from 1 patient, with no response detected in 8/8 tissues from 2 patients. hU-II is a potent cardiac stimulant with low efficacy.

Details

Title: Cardiostimulant effects of urotensin-II in human heart in vitro
Authors: Fraser D Russell (Author) - Prince Charles Hospital
P Molenaar (Author) - Prince Charles Hospital
D O'Brien (Author) - Prince Charles Hospital
Publication details: British Journal of Pharmacology, Vol.132(1), pp.5-9
Publisher: Nature Publishing Group
Date published: 2001
DOI: 10.1038/sj.bjp.0703811
ISSN: 0007-1188
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99450027702621
Output Type: Journal article

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