Journal article
Cardiopulmonary bypass induces enduring alterations to host neutrophil physiology: A single-center longitudinal observational study
Shock, Vol.30(6), pp.642-648
2008
Abstract
Studies during and immediately post-cardiopulmonary bypass (CPB) surgery have revealed that neutrophils (PMNs) are pivotal to post-CPB inflammation and innate immunity. The aim of this study was to investigate the effects of CPB on the PMN phenotype and respiratory burst function over a longer post-CPB period (up to day 5). Blood samples were collected pre-CPB and on days 1,3, and 5 post-CPB from 20 patients. Changes to PMN surface expression of CD16, CD62L, CD11b, CD18, and CD43, and PMN respiratory burst activity were measured, together with the white blood cell count and absolute PMN count. Cardiopulmonary bypass induced neutrophilia on days 1 and 3. One day post-CPB, CD16 expression reached a nadir (P= 0.001), and platelet-activating factor-induced CD18 increase was depressed (P less than 0.05). Three days post-CPB, CD43 expression peaked (P less than 0.05), with a concomitant resistance to N-formyl-Met-Leu- Phe-induced CD11b upregulation (P less than 0.05). The PMN respiratory burst activity declined continuously post-CPB until day 5. Neutrophilia on days 1 and 3 was associated with changes to surface molecules expression that may reduce PMN activation response. This study demonstrated that CPB depresses the respiratory burst activity of host PMNs for an extraordinarily longer period of at least 5 days even after neutrophilia had resolved. Collectively, the changes portray an autoprotective yet responsive homeostatic balance.
Details
- Title
- Cardiopulmonary bypass induces enduring alterations to host neutrophil physiology: A single-center longitudinal observational study
- Authors
- Yoke Lin Fung (Author) - Australian Red Cross Blood ServiceC C Silliman (Author) - Australian Red Cross Blood ServiceR M Minchinton (Author) - Australian Red Cross Blood ServiceP Wood (Author) - Princess Alexandra HospitalJ F Fraser (Author) - Prince Charles Hospital
- Publication details
- Shock, Vol.30(6), pp.642-648
- Publisher
- Lippincott Williams & Wilkins
- Date published
- 2008
- DOI
- 10.1097/SHK.0b013e318173e717
- ISSN
- 1073-2322
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99449958502621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Critical Care Medicine
- Hematology
- Peripheral Vascular Disease
- Surgery
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Source: InCites