Journal article
Cannabinoids for the treatment of spasticity
Developmental Medicine and Child Neurology, Vol.61(6), pp.631-638
2019
PMID: 30680713
Abstract
This review summarizes studies that examined the effectiveness of cannabinoids in treating spasticity, with a focus on understanding the relevance of the existing evidence to paediatric populations. MEDLINE, Embase, PsycINFO, and the Cochrane Library were searched to identify studies that examined the use of cannabinoids in spasticity. We identified 32 studies in adult and paediatric populations. Results were summarized by condition, with adult and paediatric studies considered separately. There is evidence from randomized controlled clinical trials that cannabinoids are more effective than placebo in reducing symptoms of spasticity in adults with multiple sclerosis. Most positive effects were based on patient-rated rather than clinician-rated measures, were modest in size, and should be considered in the context of the narrow therapeutic index of cannabinoids for spasticity and adverse effects. There were comparatively few, and no large studies, of spasticity in conditions other than multiple sclerosis. Few studies have been conducted in paediatric populations. Paediatric studies of spasticity provide low quality evidence and are inadequate to inform clinical practice. Cannabinoids have modest efficacy in reducing muscle spasticity in adults with multiple sclerosis. There is limited evidence of efficacy for cannabinoid use in other conditions, particularly in paediatric populations. Studies in paediatric populations have been of low quality and are insufficient to inform clinical practice.
Details
- Title
- Cannabinoids for the treatment of spasticity
- Authors
- Suzanne Nielsen (Corresponding Author) - Monash UniversityBridin Murnion (Author) - Macquarie UniversityGabrielle Campbell (Author) - UNSW AustraliaHelen Young (Author) - University of SydneyWayne Hall (Author) - University of Queensland
- Publication details
- Developmental Medicine and Child Neurology, Vol.61(6), pp.631-638
- Publisher
- Wiley-Blackwell Publishing Ltd.
- DOI
- 10.1111/dmcn.14165
- ISSN
- 1469-8749
- PMID
- 30680713
- Organisation Unit
- School of Health and Behavioural Sciences - Legacy; School of Health and Sport Sciences - Legacy; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99473408202621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Clinical Neurology
- Pediatrics
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Source: InCites