Cannabinoid receptor 1 (CNR1) gene: Impact on antidepressant treatment response and emotion processing in Major Depression

Katharina Domschke; Udo Dannlowski; Patricia Ohrmann; Bruce Lawford; Jochen Bauer; Harald Kugel; Walter Heindel; Ross Young; Phillip Morris; Volker Arolt; Jürgen Deckert; Thomas Suslow; Bernhard T Baune

doi:10.1016/j.euroneuro.2008.05.003

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Cannabinoid receptor 1 (CNR1) gene: Impact on antidepressant treatment response and emotion processing in Major Depression

Journal article

Peer reviewed

Cannabinoid receptor 1 (CNR1) gene: Impact on antidepressant treatment response and emotion processing in Major Depression

Katharina Domschke, Udo Dannlowski, Patricia Ohrmann, Bruce Lawford, Jochen Bauer, Harald Kugel, Walter Heindel, Ross Young, Phillip Morris, Volker Arolt, …

European Neuropsychopharmacology, Vol.18(10), pp.751-759

2008

DOI: https://doi.org/10.1016/j.euroneuro.2008.05.003

PMID: 18579347

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https://doi.org/10.1016/j.euroneuro.2008.05.003View

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Abstract

Depression

Endocannabinoid system

Pharmacogenetic

Anxiety

Treatment response

CNR1

The endocannabinoid system has been implicated in the pathogenesis of depression and anxiety, the mediation of antidepressant drug effects in animal models and the neurobiology of emotion processing in healthy volunteers. Therefore, the impact of cannabinoid receptor 1 gene ( CNR1) variants rs1049353 and rs12720071 on antidepressant treatment response was evaluated in 256 Caucasian patients with Major Depression. A subsample of 33 depressed patients was additionally scanned by fMRI under visual presentation of emotional faces. The CNR1 rs1049353 G allele conferred an increased risk of antidepressant treatment resistance, particularly in female patients with high comorbid anxiety. CNR1 rs1049353 G allele carriers also demonstrated weaker bilateral amygdala, putamen and pallidum activity as well as left lateralized caudate and thalamus activity in response to masked happy faces. This analysis provides preliminary support for a role of CNR1 gene variation in depression and anxiety, potentially mediated by subcortical hypo-responsiveness to social reward stimuli.

Details

Title: Cannabinoid receptor 1 (CNR1) gene: Impact on antidepressant treatment response and emotion processing in Major Depression
Authors: Katharina Domschke (Author) - University of Münster
Udo Dannlowski (Author) - University of Münster
Patricia Ohrmann (Author) - University of Münster
Bruce Lawford (Author) - Royal Brisbane Hospital
Jochen Bauer (Author) - University of Münster
Harald Kugel (Author) - University of Münster
Walter Heindel (Author) - University of Münster
Ross Young (Author) - Queensland University of Technology
Phillip Morris (Author) - Queensland University of Technology
Volker Arolt (Author) - University of Münster
Jürgen Deckert (Author) - University of Würzburg
Thomas Suslow (Author) - University of Münster
Bernhard T Baune (Author) - University of Münster
Publication details: European Neuropsychopharmacology, Vol.18(10), pp.751-759
Publisher: Elsevier BV
DOI: 10.1016/j.euroneuro.2008.05.003
ISSN: 1873-7862
PMID: 18579347
Organisation Unit: Office of the Deputy Vice-Chancellor (Research and Innovation); University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99551004402621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry

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