Calcium and endothelium-mediated vasodilator signaling

Shaun L Sandow; S Senadheera; T Hilton Grayson; D G Welsh; T V Murphy

doi:10.1007/978-94-007-2888-2_36

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Calcium and endothelium-mediated vasodilator signaling

Journal article

Peer reviewed

Calcium and endothelium-mediated vasodilator signaling

Shaun L Sandow, S Senadheera, T Hilton Grayson, D G Welsh and T V Murphy

Advances in Experimental Medicine and Biology, Vol.740, pp.811-831

2012

DOI: https://doi.org/10.1007/978-94-007-2888-2_36

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Abstract

artery

endothelium

calcium-activated potassium channel

smooth muscle

vasodilation

Vascular tone refers to the balance between arterial constrictor and dilator activity. The mechanisms that underlie tone are critical for the control of haemodynamics and matching circulatory needs with metabolism, and thus alterations in tone are a primary factor for vascular disease etiology. The dynamic spatiotemporal control of intracellular Ca 2+ levels in arterial endothelial and smooth muscle cells facilitates the modulation of multiple vascular signaling pathways. Thus, control of Ca 2+ levels in these cells is integral for the maintenance of tone and blood flow, and intimately associated with both physiological and pathophysiological states. Hence, understanding the mechanisms that underlie the modulation of vascular Ca 2+ activity is critical for both fundamental knowledge of artery function, and for the development of targeted therapies. This brief review highlights the role of Ca 2+ signaling in vascular endothelial function, with a focus on contact-mediated vasodilator mechanisms associated with endothelium-derived hyperpolarization and the longitudinal conduction of responses over distance. © 2012 Springer Science+Business Media B.V.

Details

Title: Calcium and endothelium-mediated vasodilator signaling
Authors: Shaun L Sandow (Author) - University of New South Wales
S Senadheera (Author) - University of New South Wales
T Hilton Grayson (Author) - University of Calgary, Canada
D G Welsh (Author) - University of Calgary, Canada
T V Murphy (Author) - University of New South Wales
Publication details: Advances in Experimental Medicine and Biology, Vol.740, pp.811-831
Publisher: Springer New York LLC
Date published: 2012
DOI: 10.1007/978-94-007-2888-2_36
ISSN: 0065-2598
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99448627502621
Output Type: Journal article

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Web Of Science research areas: Medicine, Research & Experimental; Neurosciences

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