Journal article
Calcium and cancer: targeting Ca2+ transport
Nature Reviews. Cancer, Vol.7, pp.519-530
2007
PMID: 17585332
Abstract
Ca2+ is a ubiquitous cellular signal. Altered expression of specific Ca2+ channels and pumps are characterizing features of some cancers. The ability of Ca2+ to regulate both cell death and proliferation, combined with the potential for pharmacological modulation, offers the opportunity for a set of new drug targets in cancer. However, the ubiquity of the Ca2+ signal is often mistakenly presumed to thwart the specific therapeutic targeting of proteins that transport Ca2+. This Review presents evidence to the contrary and addresses the question: which Ca2+ channels and pumps should be targeted?
Details
- Title
- Calcium and cancer: targeting Ca2+ transport
- Authors
- Gregory R Monteith (Author) - University of QueenslandDamara McAndrew (Author) - University of QueenslandHelen Faddy (Author) - University of QueenslandSarah J Roberts-Thomson (Author) - University of Queensland
- Publication details
- Nature Reviews. Cancer, Vol.7, pp.519-530
- Publisher
- Nature Publishing Group
- DOI
- 10.1038/nrc2171
- ISSN
- 1474-1768
- PMID
- 17585332
- Organisation Unit
- School of Health and Behavioural Sciences - Legacy; School of Health and Sport Sciences - Legacy; University of the Sunshine Coast, Queensland; School of Health - Biomedicine
- Language
- English
- Record Identifier
- 99477806202621
- Output Type
- Journal article
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- Oncology
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Source: InCites