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Published VersionCC BY-NC-ND V4.0, Open Access
Journal article
Caerin 1.9–Titanium Plates Aid Implant Healing and Inhibit Bacterial Growth in New Zealand Rabbit Mandibles
International Dental Journal, Vol.74(6), pp.1287-1297
2024
Abstract
Objectives
With rising rates of maxillofacial fracture, postoperative infection following rigid internal fixation is an important issue that requires immediate resolution. It is important to explore an alternative antibacterial method apart from conventional antibiotics. A controlled experiment was conducted to evaluate the effectiveness of a caerin 1.9 peptide–coated titanium plate in reducing mandibular infection in New Zealand (NZ) rabbits, aiming to minimise the risk of post–metallic implantation infection.
Methods
Twenty-two NZ rabbits were randomly divided into 3 groups. The experiment group received caerin 1.9 peptide–coated titanium plates and mixed oral bacteria exposure. The control group received normal titanium plates with mixed oral bacteria exposure. The untreated group served as a control to prove that bacteria in the mouth can cause infection. Weight, temperature, hepatic function, and C-reactive protein levels were measured. Wound and bone conditions were evaluated. Further analysis included local infection, anatomic conditions, histology, and bacterial load.
Results
No significant differences were found in temperature, weight, blood alanine aminotransferase, and C-reactive protein levels amongst the 3 groups. The experiment group showed the lowest amount of bacterial RNA in wounds. Additionally, the experiment group had higher peripheral lymphocyte counts compared to the control group and lower neutrophil counts on the third and seventh day postoperatively. Histologic analysis revealed lower levels of inflammatory cell infiltration, bleeding, and areas of necrosis in the experimental group compared with the controls.
Conclusions
A caerin 1.9–coated titanium plate is able to inhibit bacterial growth in a NZ rabbit mandibular mixed bacteria infection model and is worth further investigation.
Details
- Title
- Caerin 1.9–Titanium Plates Aid Implant Healing and Inhibit Bacterial Growth in New Zealand Rabbit Mandibles
- Authors
- Yuqing Long - Zunyi Medical UniversityXubo Duan - Guiyang Medical UniversityQuanlan Fu - Guiyang UniversityMengqi Liu - Guiyang Medical UniversityJiawei Fu - Guangdong Pharmaceutical UniversityXinyi Song - Guangdong Pharmaceutical UniversityRongmi Mo - Guangdong Pharmaceutical UniversityHang You - Zunyi Medical UniversityLi Qin - Zunyi Medical UniversityTianfang Wang - University of the Sunshine Coast, Queensland, Centre for BioinnovationHejie Li - University of the Sunshine Coast, Queensland, GeneCology Research Centre - LegacyGuoying Ni - University of the Sunshine Coast, Queensland, GeneCology Research Centre - LegacyXiaosong Liu - First People's Hospital of FoshanWei Yang - Guizhou University
- Publication details
- International Dental Journal, Vol.74(6), pp.1287-1297
- Publisher
- Elsevier BV
- Date published
- 2024
- DOI
- 10.1016/j.identj.2024.04.020
- ISSN
- 1875-595X; 0020-6539
- Copyright note
- (c) 2024 Published by Elsevier Inc. on behalf of FDI World Dental Federation. This is an open access article under the CC BY-NCND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
- Grant note
- This work was supported by Guizhou Provincial Department of Science and Technology (Qiankehe support normal [2022] No. 196).
- Organisation Unit
- School of Science and Engineering - Legacy; GeneCology Research Centre - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 991046398402621
- Output Type
- Journal article
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