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Caerin 1.1 and 1.9 Peptides from Australian Tree Frog Inhibit Antibiotic-Resistant Bacteria Growth in a Murine Skin Infection Model1.34 MB
Published VersionCC BY V4.0, Open Access
Journal article
Caerin 1.1 and 1.9 Peptides from Australian Tree Frog Inhibit Antibiotic-Resistant Bacteria Growth in a Murine Skin Infection Model
Microbiology Spectrum, Vol.9(1), pp.1-12
2021
Abstract
The host defense peptide caerin 1.9 was originally isolated from skin secretions of an Australian tree frog and inhibits the growth of a wide range of bacteria in vitro . In this study, we demonstrated that caerin 1.9 shows high bioactivity against several bacteria strains, such as Staphylococcus aureus , Acinetobacter baumannii , methicillin-resistant Staphylococcus aureus (MRSA), and Streptococcus haemolyticus in vitro . Importantly, unlike the antibiotic Tazocin, caerin 1.9 does not induce bacterial resistance after 30 rounds of in vitro culture. Moreover, caerin 1.1, another peptide of the caerin family, has an additive antibacterial effect when used together with caerin 1.9. Furthermore, caerin 1.1 and 1.9 prepared in the form of a temperature-sensitive gel inhibit MRSA growth in a skin bacterial infection model of two murine strains. These results indicate that caerin 1.1 and 1.9 peptides could be considered an alternative for conventional antibiotics. IMPORTANCE Antibiotic-resistant bacteria cause severe problems in the clinic. We show in our paper that two short peptides isolated from an Australian frog and prepared in the form of a gel are able to inhibit the growth of antibiotic-resistant bacteria in mice, and, unlike antibiotics, these peptides do not lead to the development of peptide-resistant bacteria strains.
Details
- Title
- Caerin 1.1 and 1.9 Peptides from Australian Tree Frog Inhibit Antibiotic-Resistant Bacteria Growth in a Murine Skin Infection Model
- Authors
- Shu Chen (Author) - First People's Hospital of FoshanPingping Zhang (Author) - First People's Hospital of FoshanLiyin Xiao (Author) - First People's Hospital of FoshanYing Liu (Author) - First People's Hospital of FoshanKuihai Wu (Author) - First People's Hospital of FoshanGuoying Ni (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - LegacyHejie Li (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - LegacyTianfang Wang (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - LegacyXiaolian Wu (Author) - First People's Hospital of FoshanGuoqiang Chen (Author) - First People's Hospital of FoshanXiaosong Liu (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - Legacy
- Publication details
- Microbiology Spectrum, Vol.9(1), pp.1-12
- Publisher
- American Society for Microbiology
- Date published
- 2021
- DOI
- 10.1128/Spectrum.00051-21
- ISSN
- 2165-0497
- Copyright note
- Copyright © 2021 Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99583608802621
- Output Type
- Journal article
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