CXCL10, CXCL11, HLA-A and IL-1β are induced in peripheral blood mononuclear cells from women with Chlamydia trachomatis related infertility

Shruti Menon; Kimberly Alexander; Peter Timms; John A Allan; Wilhelmina M Huston

doi:10.1093/femspd/ftv099

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CXCL10, CXCL11, HLA-A and IL-1β are induced in peripheral blood mononuclear cells from women with Chlamydia trachomatis related infertility

Journal article

Peer reviewed

CXCL10, CXCL11, HLA-A and IL-1β are induced in peripheral blood mononuclear cells from women with Chlamydia trachomatis related infertility

Shruti Menon, Kimberly Alexander, Peter Timms, John A Allan and Wilhelmina M Huston

Pathogens and Disease, Vol.74(1), pp.1-7

2016

DOI: https://doi.org/10.1093/femspd/ftv099

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Abstract

chlamydia

infertility

pathology

Chlamydia trachomatis infections can result in the development of serious sequelae such as pelvic inflammatory disease and tubal infertility. In this study, peripheral blood mononuclear cells from women who were undergoing or had recently undergone IVF treatment were cultured ex vivo with C. trachomatis to identify the immune responses associated with women who had serological evidence of a history of Chlamydia infection. Cytokines secreted into the supernatant from the cultures were measured using ELISA, and the level of IL-1β was found to be significantly higher in Chlamydia positive women than Chlamydia negative women. qRT-PCR analysis of the expression of 88 immune-related genes showed trends towards an upregulation of CXCL10, CXCL11 and HLA-A in Chlamydia positive women compared with Chlamydia negative women. These findings support that some women launch a more marked proinflammatory response upon infection with C. trachomatis and this may be associated with why C. trachomatis induces infertility in some infected women.

Details

Title: CXCL10, CXCL11, HLA-A and IL-1β are induced in peripheral blood mononuclear cells from women with Chlamydia trachomatis related infertility
Authors: Shruti Menon (Author) - Queensland University of Technology
Kimberly Alexander (Author) - Queensland University of Technology
Peter Timms (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
John A Allan (Author) - Wesley Hospital
Wilhelmina M Huston (Author) - Queensland University of Technology
Publication details: Pathogens and Disease, Vol.74(1), pp.1-7
Publisher: Oxford University Press
Date published: 2016
DOI: 10.1093/femspd/ftv099
ISSN: 2049-632X
Organisation Unit: University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99449599302621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Immunology; Infectious Diseases; Microbiology

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Source: InCites