Journal article
CTA1-DD is an effective adjuvant for targeting anti-chlamydial immunity to the murine genital mucosa
Journal of Reproductive Immunology, Vol.81(1), pp.34-38
2009
Abstract
Chlamydia trachomatis is a significant human pathogen with potentially severe disease sequelae in the genital tract, including infertility. A successful vaccine will need to effectively target immunity to the genital mucosa. Intranasal immunisation with cholera toxin (CT) can target immunity to the genital tract, but has the potential to cause neurological side effects. CTA1-DD is a non-toxic potent mucosal adjuvant which combines the enzymatic properties of CT, with a B cell targeting moiety. Here, we demonstrate that intranasal immunisation with CTA1-DD and chlamydial Major Outer Membrane Protein (MOMP) results in the induction of neutralising systemic and mucosal antibodies, and reduces the level of chlamydial shedding following intravaginal challenge with Chlamydia muridarum. Thus, CTA1-DD is an effective adjuvant for vaccine development against Chlamydia trachomatis, and possibly also a range of other genital pathogens. © 2009 Elsevier Ireland Ltd. All rights reserved.
Details
- Title
- CTA1-DD is an effective adjuvant for targeting anti-chlamydial immunity to the murine genital mucosa
- Authors
- K A Cunningham (Author) - Queensland University of TechnologyA J Carey (Author) - Queensland University of TechnologyN Lycke (Author) - University of Gothenburg, SwedenPeter Timms (Author) - Queensland University of TechnologyK W Beagley (Author) - Queensland University of Technology
- Publication details
- Journal of Reproductive Immunology, Vol.81(1), pp.34-38
- Publisher
- Elsevier Ireland Ltd.
- Date published
- 2009
- DOI
- 10.1016/j.jri.2009.04.002
- ISSN
- 0165-0378
- Copyright note
- Copyright © 2009. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- University of the Sunshine Coast, Queensland; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99448753702621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Immunology
- Obstetrics & Gynecology
- Reproductive Biology
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