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Published VersionCC BY V4.0, Open Access
Journal article
CSGene: a literature-based database for cell senescence genes and its application to identify critical cell aging pathways and associated diseases
Cell Death and Disease, Vol.7, pp.1-10
2016
Appears in UniSC Supported Open Access Outputs
Abstract
Cell senescence is a cellular process in which normal diploid cells cease to replicate and is a major driving force for human cancers and aging-associated diseases. Recent studies on cell senescence have identified many new genetic components and pathways that control cell aging. However, there is no comprehensive resource for cell senescence that integrates various genetic studies and relationships with cell senescence, and the risk associated with complex diseases such as cancer is still unexplored. We have developed the first literature-based gene resource for exploring cell senescence genes, CSGene. We complied 504 experimentally verified genes from public data resources and published literature. Pathway analyses highlighted the prominent roles of cell senescence genes in the control of rRNA gene transcription and unusual rDNA repeat that constitute a center for the stability of the whole genome. We also found a strong association of cell senescence with HIV-1 infection and viral carcinogenesis that are mainly related to promoter/enhancer binding and chromatin modification processes. Moreover, pan-cancer mutation and network analysis also identified common cell aging mechanisms in cancers and uncovered a highly modular network structure. These results highlight the utility of CSGene for elucidating the complex cellular events of cell senescence.
Details
- Title
- CSGene: a literature-based database for cell senescence genes and its application to identify critical cell aging pathways and associated diseases
- Authors
- Min Zhao (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringL Chen (Author) - Peking University, ChinaH Qu (Author) - Peking University, China
- Publication details
- Cell Death and Disease, Vol.7, pp.1-10
- Publisher
- Nature Publishing Group
- Date published
- 2016
- DOI
- 10.1038/cddis.2015.414
- ISSN
- 2041-4889
- Copyright note
- Copyright © 2016 The Authors. Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- Organisation Unit
- School of Science and Engineering - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99449113002621
- Output Type
- Journal article
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