Journal article
CD4+ T cells reduce the tissue burden of Chlamydia muridarum in male BALB/c mice
Vaccine, Vol.28(31), pp.4861-4863
2010
Abstract
Male chlamydial infections are becoming more recognised as an aetiological agent in infertility. An IFN-γ response is required for protection against Chlamydia in females, but may have the potential to induce pathology in the immune-privileged male reproductive tract. We examined the induction of immunity following intranasal immunisation with major outer membrane protein (MOMP) of Chlamydia muridarum in male BALB/c mice, and the role of MOMP-specific CD4+ T cells in clearance of an intrapenile infection. Here we report that adoptive transfer of MOMP-specific CD4+ T cells into naïve mice confers partial protective immunity, which significantly reduces the tissue burden of Chlamydia.
Details
- Title
- CD4+ T cells reduce the tissue burden of Chlamydia muridarum in male BALB/c mice
- Authors
- K A Cunningham (Author) - Queensland University of TechnologyA J Carey (Author) - Queensland University of TechnologyPeter Timms (Author) - Queensland University of TechnologyK W Beagley (Author) - Queensland University of Technology
- Publication details
- Vaccine, Vol.28(31), pp.4861-4863
- Publisher
- Elsevier Ltd.
- Date published
- 2010
- DOI
- 10.1016/j.vaccine.2010.05.050
- ISSN
- 0264-410X
- Organisation Unit
- University of the Sunshine Coast, Queensland; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99448721902621
- Output Type
- Journal article
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- Immunology
- Medicine, Research & Experimental
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Source: InCites