Bromocriptine in the treatment of alcoholics with the D2 dopamine receptor A1 allele

Bruce R Lawford; Ross Young; John A Rowell; Joan Qualichefski; Barbara H Fletcher; Karl Syndulko; Terry Ritchie; Ernest P Noble

doi:10.1038/nm0495-337

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Bromocriptine in the treatment of alcoholics with the D2 dopamine receptor A1 allele

Journal article

Peer reviewed

Bromocriptine in the treatment of alcoholics with the D2 dopamine receptor A1 allele

Bruce R Lawford, Ross Young, John A Rowell, Joan Qualichefski, Barbara H Fletcher, Karl Syndulko, Terry Ritchie and Ernest P Noble

Nature Medicine, Vol.1(4), pp.337-341

1995

DOI: https://doi.org/10.1038/nm0495-337

PMID: 7585063

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Abstract

Various types of alcoholics have been described and heredity has been shown to be involved in some of these types. An important role of the mesolimbic dopamine system has been suggested in the reinforcing effects of alcohol and recent molecular genetic studies are implicating the gene for the D2 dopamine receptor (DRD2) in alcoholism. In a double-blind study, bromocriptine, a DRD2 agonist, or placebo was administered to alcoholics with either the A1 (A1/A1 and A1/A2 genotypes) or only the A2 (A2/A2 genotype) allele of the DRD2 gene. The greatest improvement in craving and anxiety occurred in the bromocriptine-treated A1 alcoholics and attrition was highest in the placebo-treated A1 alcoholics. The feasibility of a pharmacogenetic approach in treating certain types of alcoholics is suggested.

Details

Title: Bromocriptine in the treatment of alcoholics with the D2 dopamine receptor A1 allele
Authors: Bruce R Lawford (Author) - Royal Brisbane Hospital
Ross Young (Author) - University of Queensland
John A Rowell (Author) - Royal Brisbane Hospital
Joan Qualichefski (Author) - Royal Brisbane Hospital
Barbara H Fletcher (Author) - Royal Brisbane Hospital
Karl Syndulko (Author) - United States Department of Veterans Affairs
Terry Ritchie (Author) - University of California Los Angeles
Ernest P Noble (Author) - University of California Los Angeles
Publication details: Nature Medicine, Vol.1(4), pp.337-341
Publisher: Nature Publishing Group
DOI: 10.1038/nm0495-337
ISSN: 1546-170X
PMID: 7585063
Organisation Unit: University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
Language: English
Record Identifier: 99551004602621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental

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