Bridging the gap: is Chlamydia trachomatis a risk factor for developing adenomyosis?

Melinda Doyle; Martina Jelocnik; Bess Nayda; Wilhelmina M Huston; Samuel Phillips

doi:10.1186/s12905-026-04810-7

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Bridging the gap: is Chlamydia trachomatis a risk factor for developing adenomyosis?

Journal article

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Bridging the gap: is Chlamydia trachomatis a risk factor for developing adenomyosis?

Melinda Doyle, Martina Jelocnik, Bess Nayda, Wilhelmina M Huston and Samuel Phillips

BMC Women's Health, Vol.Advanced access

21-Aug-2026

DOI: https://doi.org/10.1186/s12905-026-04810-7

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Abstract

Chlamydia trachomatis

adenomyosis

pathogenesis

inflammation

mesenchymal cell

reproductive health

Chlamydia trachomatis and adenomyosis are prevalent health issues significantly impacting women’s reproductive health. While adenomyosis is characterised by endometrial tissue invading the myometrium, C. trachomatis is linked to chronic reproductive disease in women such as pelvic inflammatory disease. Despite increasing prevalence of both conditions, the potential link between them remains underexplored. Chronic inflammation and epithelial-mesenchymal transition induced by C. trachomatis may contribute to the pathogenesis of adenomyosis, particularly through inflammatory cytokines, matrix metalloproteinases, and hormonal dysregulation. This review aims to establish a foundation for future research to unravel the potential molecular process that may link C. trachomatis infection and adenomyosis. Understanding these connections could lead to the development of enhanced diagnostic techniques and targeted therapeutic interventions, consequently improving patient outcomes in reproductive health.

Details

Title: Bridging the gap: is Chlamydia trachomatis a risk factor for developing adenomyosis?
Authors: Melinda Doyle - University of the Sunshine Coast
Martina Jelocnik - University of the Sunshine Coast
Bess Nayda - Quantum Medical Imaging (Australia)
Wilhelmina M Huston - University of Technology Sydney
Samuel Phillips (Corresponding Author) - University of the Sunshine Coast
Publication details: BMC Women's Health, Vol.Advanced access
Publisher: BioMed Central Ltd.
DOI: 10.1186/s12905-026-04810-7
ISSN: 1472-6874
Copyright note: This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
Data Availability: Not applicable.
Grants: Identifying links between Chlamydia trachomatis infection and adenomyosis, 0980029585, University of the Sunshine Coast (Australia, Sunshine Coast) - UniSC
Organisation Unit: School of Health - Biomedicine; School of Health; School of Science, Technology and Engineering
Language: English
Record Identifier: 991260496002621
Output Type: Journal article

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