Files and links (2)
Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder_ results from the ENIGMA MDD Working Group869.93 kB
Published VersionCC BY V4.0, Open Access
Journal article
Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group
Translational Psychiatry, Vol.10(1), pp.1-11
2020
PMID: 33293520
Appears in Thompson Institute Research Collection
Abstract
It has been difficult to find robust brain structural correlates of the overall severity of major depressive disorder (MDD). We hypothesized that specific symptoms may better reveal correlates and investigated this for the severity of insomnia, both a key symptom and a modifiable major risk factor of MDD. Cortical thickness, surface area and subcortical volumes were assessed from T1-weighted brain magnetic resonance imaging (MRI) scans of 1053 MDD patients (age range 13-79 years) from 15 cohorts within the ENIGMA MDD Working Group. Insomnia severity was measured by summing the insomnia items of the Hamilton Depression Rating Scale (HDRS). Symptom specificity was evaluated with correlates of overall depression severity. Disease specificity was evaluated in two independent samples comprising 2108 healthy controls, and in 260 clinical controls with bipolar disorder. Results showed that MDD patients with more severe insomnia had a smaller cortical surface area, mostly driven by the right insula, left inferior frontal gyrus pars triangularis, left frontal pole, right superior parietal cortex, right medial orbitofrontal cortex, and right supramarginal gyrus. Associations were specific for insomnia severity, and were not found for overall depression severity. Associations were also specific to MDD; healthy controls and clinical controls showed differential insomnia severity association profiles. The findings indicate that MDD patients with more severe insomnia show smaller surfaces in several frontoparietal cortical areas. While explained variance remains small, symptom-specific associations could bring us closer to clues on underlying biological phenomena of MDD.
Details
- Title
- Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group
- Authors
- Jeanne Leerssen (Corresponding Author) - Royal Netherlands Academy of Arts and SciencesTessa F Blanken (Author) - VU University AmsterdamElena Pozzi (Author) - The University of MelbourneNeda Jahanshad (Author) - University of Southern CaliforniaLyubomir Aftanas (Author) - Novosibirsk State UniversityOle A Andreassen (Author) - Oslo University HospitalBernhard T Baune (Author) - University of MünsterIvan Brack (Author) - Scientific Research Institute of Neuroscience & MedicineAngela Carballedo (Author) - Trinity College DublinChristopher R. K Ching (Author) - University of Southern CaliforniaUdo Dannlowski (Author) - University of MünsterKatharina Dohm (Author) - University of MünsterVerena Enneking (Author) - University of MünsterElena Filimonova (Author) - Scientific Research Institute of Neuroscience & MedicineStella M Fingas (Author) - University of MünsterThomas Frodl (Author) - Trinity College DublinJanik Goltermann (Author) - University of MünsterBeata R Godlewska (Author) - University of OxfordIan H Gotlib (Author) - Stanford UniversityOliver Gruber (Author) - Heidelberg UniversityDominik Grotegerd (Author) - University of MünsterMathew A Harris (Author) - University of EdinburghSean N Hatton (Author) - The University of SydneyEmma Hawkins (Author) - University of EdinburghIan B Hickie (Author) - The University of SydneyNatalia Jaworska (Author) - University of OttawaTilo Kircher (Author) - Philipps University of MarburgAxel Krug (Author) - Philipps University of MarburgJim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteHannah Lemke (Author) - University of MünsterMeng Li (Author) - Jena University HospitalFrank P MacMaster (Author) - University of CalgaryAndrew M McIntosh (Author) - University of EdinburghQuinn McLellan (Author) - University of CalgarySusanne Meinert (Author) - University of MünsterBenson Mwangi (Author) - The University of Texas Health Science Center at HoustonIgor Nenadić (Author) - Philipps University of MarburgEvgeny Osipov (Author) - Scientific Research Institute of Neuroscience & MedicineMaria J Portella (Author) - Institut d'Investigacions Biomèdiques de BarcelonaJonathan Repple (Author) - University of MünsterRonny Redlich (Author) - University of MünsterMatthew D Sacchet (Author) - Harvard Medical SchoolPhilipp G Sämann (Author) - Max Planck Institute of PsychiatryEgle Simulionyte (Author) - Heidelberg UniversityJair C Soares (Author) - The University of Texas Health Science Center at HoustonMartin Walter (Author) - Jena University HospitalNorio Watanabe (Author) - Kyoto UniversityHeather C Whalley (Author) - University of EdinburghDilara Yüksel (Author) - Philipps University of MarburgDick J Veltman (Author) - Amsterdam UMC - Vrije Universiteit AmsterdamPaul M Thompson (Author) - University of Southern CaliforniaLianne Schmaal (Author) - The University of MelbourneEus J. W Van Someren (Author) - Royal Netherlands Academy of Arts and Sciences
- Publication details
- Translational Psychiatry, Vol.10(1), pp.1-11
- Publisher
- Nature Publishing Group
- Date published
- 2020
- DOI
- 10.1038/s41398-020-01109-5
- ISSN
- 2158-3188
- PMID
- 33293520
- Copyright note
- © The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99498108702621
- Output Type
- Journal article
Metrics
7 File views/ downloads
24 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Psychiatry
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites