Journal article
Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders : Evidence through univariate and multivariate mega-analysis including 6420 participants from the ENIGMA MDD working group
Molecular Psychiatry, Vol.26, pp.4839-4852
2021
PMCID: PMC8589644
PMID: 32467648
Appears in Thompson Institute Research Collection
Abstract
Emerging evidence suggests that obesity impacts brain physiology at multiple levels. Here we aimed to clarify the relationship between obesity and brain structure using structural MRI (n = 6420) and genetic data (n = 3907) from the ENIGMA Major Depressive Disorder (MDD) working group. Obesity (BMI > 30) was significantly associated with cortical and subcortical abnormalities in both mass-univariate and multivariate pattern recognition analyses independent of MDD diagnosis. The most pronounced effects were found for associations between obesity and lower temporo-frontal cortical thickness (maximum Cohen´s d (left fusiform gyrus) = -0.33). The observed regional distribution and effect size of cortical thickness reductions in obesity revealed considerable similarities with corresponding patterns of lower cortical thickness in previously published studies of neuropsychiatric disorders. A higher polygenic risk score for obesity significantly correlated with lower occipital surface area. In addition, a significant age-by-obesity interaction on cortical thickness emerged driven by lower thickness in older participants. Our findings suggest a neurobiological interaction between obesity and brain structure under physiological and pathological brain conditions.
Details
- Title
- Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders : Evidence through univariate and multivariate mega-analysis including 6420 participants from the ENIGMA MDD working group
- Authors
- Nils Opel (Corresponding Author) - University of MünsterAnbupalam Thalamuthu (Author) - Neuroscience Research AustraliaYuri Milaneschi (Author) - Amsterdam UMC - Vrije Universiteit AmsterdamDominik Grotegerd (Author) - University of MünsterClaas Flint (Author) - University of MünsterRamona Leenings (Author) - University of MünsterJanik Goltermann (Author) - University of MünsterMaike Richter (Author) - University of MünsterTim Hahn (Author) - University of MünsterGeorg Woditsch (Author) - University of MünsterKlaus Berger (Author) - University of MünsterMarco Hermesdorf (Author) - University of MünsterAndrew McIntosh (Author) - University of EdinburghHeather C Whalley (Author) - University of EdinburghMathew A Harris (Author) - University of EdinburghFrank P MacMaster (Author) - University of CalgaryHenrik Walter (Author) - CharitéIlya M Veer (Author) - CharitéThomas Frodl (Author) - Trinity College DublinAxel Krug (Author) - Philipps University of MarburgAngela Carballedo (Author) - Trinity College DublinIgor Nenadic (Author) - Philipps University of MarburgTilo Kircher (Author) - Philipps University of MarburgAndre Aleman (Author) - University Medical Center GroningenNynke A Groenewold (Author) - University Medical Center GroningenDan J Stein (Author) - University of Cape TownJair C Soares (Author) - The University of Texas Health Science Center at HoustonGiovana B Zunta-Soares (Author) - The University of Texas Health Science Center at HoustonBenson Mwangi (Author) - The University of Texas Health Science Center at HoustonMon-Ju Wu (Author) - The University of Texas Health Science Center at HoustonMartin Walter (Author) - Jena University HospitalMeng Li (Author) - Jena University HospitalBen J Harrison (Author) - The University of MelbourneChristopher G Davey (Author) - The University of MelbourneKathryn R Cullen (Author) - University of MinnesotaBonnie Klimes-Dougan (Author) - University of MinnesotaBryon A Mueller (Author) - University of MinnesotaPhilipp G Sämann (Author) - Max Planck Institute of PsychiatryBrenda Penninx (Author) - Amsterdam UMC - Vrije Universiteit AmsterdamDick J Veltman (Author) - Amsterdam UMC - Vrije Universiteit AmsterdamLaura Nawijn (Author) - Amsterdam UMC - Vrije Universiteit AmsterdamLyubomir Aftanas (Author) - Novosibirsk State UniversityIvan V Brak (Author) - Novosibirsk State UniversityElena A Filimonova (Author) - Novosibirsk State UniversityEvgeniy A Osipov (Author) - Novosibirsk State UniversityLiesbeth Reneman (Author) - University of AmsterdamAnouk Schrantee (Author) - University of AmsterdamHans J Grabe (Author) - Universität GreifswaldSandra Van der Auwera (Author) - Universität GreifswaldKatharina Wittfeld (Author) - Universität GreifswaldNorbert Hosten (Author) - Universität GreifswaldHenry Völzke (Author) - Universität GreifswaldKang Sim (Author) - Institute of Mental HealthIan H Gotlib (Author) - Stanford UniversityMatthew D Sacchet (Author) - Harvard Medical SchoolIan Hickie (Author) - The University of SydneyElena Pozzi (Author) - The University of MelbournePaul M Thompson (Author) - University of Southern CaliforniaNeda Jahanshad (Author) - University of Southern CaliforniaJim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteLianne Schmaal (Author) - The University of MelbourneBernhard T Baune (Author) - University of MünsterUdo Dannlowski (Author) - University of MünsterSean N Hatton (Author) - The University of Sydney
- Publication details
- Molecular Psychiatry, Vol.26, pp.4839-4852
- Publisher
- Nature Publishing Group
- Date published
- 2021
- DOI
- 10.1038/s41380-020-0774-9
- ISSN
- 1476-5578
- PMID
- 32467648; PMC8589644
- Copyright note
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Grants
- Grant note
- See full text of article for complete list of funders.
- Organisation Unit
- Thompson Institute
- Language
- English
- Record Identifier
- 99471408502621
- Output Type
- Journal article
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