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Published VersionCC BY V4.0, Open Access
Journal article
Brain-specific epigenetic markers of schizophrenia
Translational Psychiatry, Vol.5(11), e680
2015
PMCID: PMC5068768
PMID: 26575221
Abstract
Epigenetics plays a crucial role in schizophrenia susceptibility. In a previous study, we identified over 4500 differentially methylated sites in prefrontal cortex (PFC) samples from schizophrenia patients. We believe this was the first genome-wide methylation study performed on human brain tissue using the Illumina Infinium HumanMethylation450 Bead Chip. To understand the biological significance of these results, we sought to identify a smaller number of differentially methylated regions (DMRs) of more functional relevance compared with individual differentially methylated sites. Since our schizophrenia whole genome methylation study was performed, another study analysing two separate data sets of post-mortem tissue in the PFC from schizophrenia patients has been published. We analysed all three data sets using the bumphunter function found in the Bioconductor package minfi to identify regions that are consistently differentially methylated across distinct cohorts. We identified seven regions that are consistently differentially methylated in schizophrenia, despite considerable heterogeneity in the methylation profiles of patients with schizophrenia. The regions were near CERS3, DPPA5, PRDM9, DDX43, REC8, LY6G5C and a region on chromosome 10. Of particular interest is PRDM9 which encodes a histone methyltransferase that is essential for meiotic recombination and is known to tag genes for epigenetic transcriptional activation. These seven DMRs are likely to be key epigenetic factors in the aetiology of schizophrenia and normal brain neurodevelopment.
Details
- Title
- Brain-specific epigenetic markers of schizophrenia
- Authors
- L F Wockner (Author) - QIMR Berghofer Medical Research InstituteC P Morris (Author) - Queensland University of TechnologyE P Noble (Author) - University of California Los AngelesB R Lawford (Author) - Queensland University of TechnologyV L J Whitehall (Author) - QIMR Berghofer Medical Research InstituteRoss Young (Author) - Queensland University of TechnologyJoanne Voisey (Author) - Queensland University of Technology
- Publication details
- Translational Psychiatry, Vol.5(11), e680
- Publisher
- Nature Publishing Group
- Date published
- 2015
- DOI
- 10.1038/tp.2015.177
- ISSN
- 2158-3188
- PMID
- 26575221; PMC5068768
- Copyright note
- This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99551004802621
- Output Type
- Journal article
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