Journal article
Brain correlates of suicide attempt in 18,925 participants across 18 international cohorts
Biological Psychiatry, Vol.90(4), pp.243-252
2021
PMID: 34172278
Appears in Thompson Institute Research Collection
Abstract
Objective:
Neuroimaging studies of suicidal behavior have so far been conducted in small samples, prone to biases and false-positive associations, yielding inconsistent results. The ENIGMA-MDD working group aims to address the issues of poor replicability and comparability by coordinating harmonized analyses across neuroimaging studies of major depressive disorder and related phenotypes, including suicidal behavior.
Methods:
Here, we pool data from eighteen international cohorts with neuroimaging and clinical measurements in 18,925 participants (12,477 healthy controls and 6,448 people with depression, of whom 694 had attempted suicide). We compare regional cortical thickness and surface area, and measures of subcortical, lateral ventricular and intracranial volumes between suicide attempters, clinical controls (non-attempters with depression) and healthy controls.
Results:
We identified 25 regions of interest with statistically significant (FDR<0.05) differences between groups. Post-hoc examinations identified neuroimaging markers associated with suicide attempt including smaller volumes of the left and right thalamus and the right pallidum, and lower surface area of the left inferior parietal lobe.
Conclusions:
This study addresses the lack of replicability and consistency in several previously published neuroimaging studies of suicide attempt, and further demonstrates the need for well-powered samples and collaborative efforts. Our results highlight the potential involvement of the thalamus, a structure viewed historically as a passive gateway in the brain, and the pallidum, a region linked to reward response and positive affect. Future functional and connectivity studies of suicidal behaviours may focus on understanding how these regions relate to the neurobiological mechanisms of suicide attempt risk.
Details
- Title
- Brain correlates of suicide attempt in 18,925 participants across 18 international cohorts
- Authors
- Adrian I Campos (Author) - QIMR Berghofer Medical Research InstitutePaul M Thompson (Author) - University of Southern CaliforniaDick J Veltman (Author) - Amsterdam UMC Location VUmcElena Pozzi (Author) - University of MelbourneLaura S van Veltzen (Author) - University of MelbourneNeda Jahanshad (Author) - University of Southern CaliforniaMark J Adams (Author) - University of EdinburghBernhard T Baune (Author) - University of MünsterKlaus Berger (Author) - University of MünsterKatharina Brosch (Author) - Philipps University of MarburgRobin Bulow (Author) - University of GreifswaldColm G Connolly (Author) - Florida State UniversityUdo Dannlowski (Author) - University of MünsterChristopher G Davey (Author) - University of MelbourneGreig I de Zubicaray (Author) - Queensland University of TechnologyDanai Dima (Author) - University of LondonTracy Erwin-Grabner (Author) - University of GöttingenJennifer Evans (Author) - National Institute of Mental HealthCynthia H Y Fu (Author) - King's College LondonIan H Gotlib (Author) - Stanford UniversityRoberta Goya-Maldonado (Author) - University of GöttingenHans J Grabe (Author) - University of GreifswaldDominik Grotegerd (Author) - University of MünsterMatthew A Harris (Author) - University of EdinburghBen J Harrison (Author) - University of MelbourneSean N Hatton (Author) - University of SydneyMarco Hermesdorf (Author) - University of MünsterIan B Hickie (Author) - University of SydneyTiffany C Ho (Author) - University of California, San FranciscoTilo Kircher (Author) - Philipps University of MarburgAxel Krug (Author) - Philipps University of MarburgJim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteSee article full text for complete list of authors (Author)
- Contributors
- ENIGMA-MAA Working Group (Research Group)
- Publication details
- Biological Psychiatry, Vol.90(4), pp.243-252
- Publisher
- Elsevier Inc.
- Date published
- 2021
- DOI
- 10.1016/j.biopsych.2021.03.015
- ISSN
- 1873-2402
- PMID
- 34172278
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99518108402621
- Output Type
- Journal article
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- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Neurosciences
- Psychiatry
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