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Brain correlates of suicide attempt in 18,925 participants across 18 international cohorts
Journal article   Peer reviewed

Brain correlates of suicide attempt in 18,925 participants across 18 international cohorts

Adrian I Campos, Paul M Thompson, Dick J Veltman, Elena Pozzi, Laura S van Veltzen, Neda Jahanshad, Mark J Adams, Bernhard T Baune, Klaus Berger, Katharina Brosch, …
Biological Psychiatry, Vol.90(4), pp.243-252
2021
DOI: https://doi.org/10.1016/j.biopsych.2021.03.015
PMCID: PMC8324512
PMID: 34172278
Appears in  Thompson Institute Research Collection
url
https://doi.org/10.1016/j.biopsych.2021.03.015View
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Abstract

major depressive disorder structural magnetic resonance imaging suicide attempt Other Collaborations Thompson Institute Special Collection UniSC Diversity Area - Disability and Inclusion
Objective: Neuroimaging studies of suicidal behavior have so far been conducted in small samples, prone to biases and false-positive associations, yielding inconsistent results. The ENIGMA-MDD working group aims to address the issues of poor replicability and comparability by coordinating harmonized analyses across neuroimaging studies of major depressive disorder and related phenotypes, including suicidal behavior. Methods: Here, we pool data from eighteen international cohorts with neuroimaging and clinical measurements in 18,925 participants (12,477 healthy controls and 6,448 people with depression, of whom 694 had attempted suicide). We compare regional cortical thickness and surface area, and measures of subcortical, lateral ventricular and intracranial volumes between suicide attempters, clinical controls (non-attempters with depression) and healthy controls. Results: We identified 25 regions of interest with statistically significant (FDR<0.05) differences between groups. Post-hoc examinations identified neuroimaging markers associated with suicide attempt including smaller volumes of the left and right thalamus and the right pallidum, and lower surface area of the left inferior parietal lobe. Conclusions: This study addresses the lack of replicability and consistency in several previously published neuroimaging studies of suicide attempt, and further demonstrates the need for well-powered samples and collaborative efforts. Our results highlight the potential involvement of the thalamus, a structure viewed historically as a passive gateway in the brain, and the pallidum, a region linked to reward response and positive affect. Future functional and connectivity studies of suicidal behaviours may focus on understanding how these regions relate to the neurobiological mechanisms of suicide attempt risk.

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Psychiatry

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