Brain correlates of suicide attempt in 18,925 participants across 18 international cohorts

Adrian I Campos; Paul M Thompson; Dick J Veltman; Elena Pozzi; Laura S van Veltzen; Neda Jahanshad; Mark J Adams; Bernhard T Baune; Klaus Berger; Katharina Brosch; Robin Bulow; Colm G Connolly; Udo Dannlowski; Christopher G Davey; Greig I de Zubicaray; Danai Dima; Tracy Erwin-Grabner; Jennifer Evans; Cynthia H Y Fu; Ian H Gotlib; Roberta Goya-Maldonado; Hans J Grabe; Dominik Grotegerd; Matthew A Harris; Ben J Harrison; Sean N Hatton; Marco Hermesdorf; Ian B Hickie; Tiffany C Ho; Tilo Kircher; Axel Krug; Jim Lagopoulos; See article text for complete list of remaining 31 authors; ENIGMA-MDD Working Group

doi:10.1016/j.biopsych.2021.03.015

Brain correlates of suicide attempt in 18,925 participants across 18 international cohorts

Adrian I Campos, Paul M Thompson, Dick J Veltman, Elena Pozzi, Laura S van Veltzen, Neda Jahanshad, Mark J Adams, Bernhard T Baune, Klaus Berger, Katharina Brosch, …

Biological Psychiatry, Vol.90(4), pp.243-252

2021

: https://doi.org/10.1016/j.biopsych.2021.03.015

: PMC8324512

: 34172278

(1)

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Brain correlates of suicide attempt in 18,925 participants across 18 international cohorts8.94 MB

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major depressive disorder

structural magnetic resonance imaging

suicide attempt

Other Collaborations

Thompson Institute Special Collection

UniSC Diversity Area - Disability and Inclusion

Objective: Neuroimaging studies of suicidal behavior have so far been conducted in small samples, prone to biases and false-positive associations, yielding inconsistent results. The ENIGMA-MDD working group aims to address the issues of poor replicability and comparability by coordinating harmonized analyses across neuroimaging studies of major depressive disorder and related phenotypes, including suicidal behavior. Methods: Here, we pool data from eighteen international cohorts with neuroimaging and clinical measurements in 18,925 participants (12,477 healthy controls and 6,448 people with depression, of whom 694 had attempted suicide). We compare regional cortical thickness and surface area, and measures of subcortical, lateral ventricular and intracranial volumes between suicide attempters, clinical controls (non-attempters with depression) and healthy controls. Results: We identified 25 regions of interest with statistically significant (FDR<0.05) differences between groups. Post-hoc examinations identified neuroimaging markers associated with suicide attempt including smaller volumes of the left and right thalamus and the right pallidum, and lower surface area of the left inferior parietal lobe. Conclusions: This study addresses the lack of replicability and consistency in several previously published neuroimaging studies of suicide attempt, and further demonstrates the need for well-powered samples and collaborative efforts. Our results highlight the potential involvement of the thalamus, a structure viewed historically as a passive gateway in the brain, and the pallidum, a region linked to reward response and positive affect. Future functional and connectivity studies of suicidal behaviours may focus on understanding how these regions relate to the neurobiological mechanisms of suicide attempt risk.

: Brain correlates of suicide attempt in 18,925 participants across 18 international cohorts
: Adrian I Campos (Author) - QIMR Berghofer Medical Research Institute
Paul M Thompson (Author) - University of Southern California
Dick J Veltman (Author) - Amsterdam UMC Location Vrije Universiteit Amsterdam
Elena Pozzi (Author) - The University of Melbourne
Laura S van Veltzen (Author) - The University of Melbourne
Neda Jahanshad (Author) - University of Southern California
Mark J Adams (Author) - University of Edinburgh
Bernhard T Baune (Author) - University of Münster
Klaus Berger (Author) - University of Münster
Katharina Brosch (Author) - Philipps University of Marburg
Robin Bulow (Author) - Universität Greifswald
Colm G Connolly (Author) - Florida State University
Udo Dannlowski (Author) - University of Münster
Christopher G Davey (Author) - The University of Melbourne
Greig I de Zubicaray (Author) - Queensland University of Technology
Danai Dima (Author) - University of London
Tracy Erwin-Grabner (Author) - University of Göttingen
Jennifer Evans (Author) - National Institute of Mental Health
Cynthia H Y Fu (Author) - King's College London
Ian H Gotlib (Author) - Stanford University
Roberta Goya-Maldonado (Author) - University of Göttingen
Hans J Grabe (Author) - Universität Greifswald
Dominik Grotegerd (Author) - University of Münster
Matthew A Harris (Author) - University of Edinburgh
Ben J Harrison (Author) - The University of Melbourne
Sean N Hatton (Author) - The University of Sydney
Marco Hermesdorf (Author) - University of Münster
Ian B Hickie (Author) - The University of Sydney
Tiffany C Ho (Author) - University of California, San Francisco
Tilo Kircher (Author) - Philipps University of Marburg
Axel Krug (Author) - Philipps University of Marburg
Jim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
See article text for complete list of remaining 31 authors (Author)
ENIGMA-MDD Working Group (Research Group)
: Biological Psychiatry, Vol.90(4), pp.243-252
: Elsevier Inc.
: 2021
: 10.1016/j.biopsych.2021.03.015
: 1873-2402
: 34172278; PMC8324512
: Thompson Institute
: English
: 99518108402621
: Journal article

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esploro.research.conf.research.portal.label.prefix.inciteCollaboration: research.portal.fulldisplay.incitesHighlights.institutionCollaboration; research.portal.fulldisplay.incitesHighlights.internationalCollaboration
esploro.research.conf.research.portal.label.prefix.inciteWOSResearchAreas: Neurosciences; Psychiatry

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