Brain activation measured using functional magnetic resonance imaging during the Tower of London task

Inge-Andre Rasmussen; Ida Kristin Antonsen; Erik Magnus Berntsen; Jian Xu; Jim Lagopoulos; Asta Kristine Haberg

doi:10.1111/j.1601-5215.2006.00145.x

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Brain activation measured using functional magnetic resonance imaging during the Tower of London task

Journal article

Peer reviewed

Brain activation measured using functional magnetic resonance imaging during the Tower of London task

Inge-Andre Rasmussen, Ida Kristin Antonsen, Erik Magnus Berntsen, Jian Xu, Jim Lagopoulos and Asta Kristine Haberg

Acta Neuropsychiatrica, Vol.18(5), pp.216-225

2006

DOI: https://doi.org/10.1111/j.1601-5215.2006.00145.x

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Abstract

Medical and Health Sciences

Psychology and Cognitive Sciences

traumatic brain injury (TBI)

cognitive impairments

Individuals with traumatic brain injury (TBI) often suffer from a number of enduring cognitive impairments such as in attention, memory, speed of processing information and dual-task performance. The aim of this study was to assess the patterns of regional brain activation in response to the Tower of London (ToL) task in a group of patients suffering from chronic TBI using functional magnetic resonance imaging (fMRI). fMRI was performed during performance of the ToL planning task in 10 patients suffering from severe TBI and in 10 age- and sex-matched controls using a 3 T magnetic resonance scanner. Performance data showed no difference in response accuracy between the TBI group and the healthy control group. Statistical parametric brain maps showed that the TBI group activates larger and additional areas of the cerebral cortex than the healthy control group both for tasks and for a subtraction contrast between the tasks. The results of this study are interpreted as a cortical reorganization inside the executive system of vigilance and working memory in patients with TBI. Both parietal and frontal areas are recruited to compensate for damaged brain tissue.

Details

Title: Brain activation measured using functional magnetic resonance imaging during the Tower of London task
Authors: Inge-Andre Rasmussen (Author) - Norwegian University of Science and Technology, Norway
Ida Kristin Antonsen (Author) - Norwegian University of Science and Technology, Norway
Erik Magnus Berntsen (Author) - Norwegian University of Science and Technology, Norway
Jian Xu (Author) - Norwegian University of Science and Technology, Norway
Jim Lagopoulos (Author) - University of New South Wales
Asta Kristine Haberg (Author) - Norwegian University of Science and Technology, Norway
Publication details: Acta Neuropsychiatrica, Vol.18(5), pp.216-225
Publisher: Cambridge University Press
Date published: 2006
DOI: 10.1111/j.1601-5215.2006.00145.x
ISSN: 0924-2708
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99450532102621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Neurosciences; Psychiatry

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