Blocking IL-10 signalling at the time of immunization does not increase unwanted side effects in mice

Guoying Ni; Zaowen Liao; Shu Chen; Tianfang Wang; Jianwei Yuan; Xuan Pan; Kate E Mounsey; Shelley F Cavezza; Xiao Song Liu; Ming Q Wei

doi:10.1186/s12865-017-0224-x

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Blocking IL-10 signalling at the time of immunization does not increase unwanted side effects in mice

Journal article

Open access

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Blocking IL-10 signalling at the time of immunization does not increase unwanted side effects in mice

Guoying Ni, Zaowen Liao, Shu Chen, Tianfang Wang, Jianwei Yuan, Xuan Pan, Kate E Mounsey, Shelley F Cavezza, Xiao Song Liu and Ming Q Wei

BMC Immunology, Vol.18, 40

2017

DOI: https://doi.org/10.1186/s12865-017-0224-x

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Abstract

Il-10

CD4+ T cells

intestine

inflammation

immunotherapy

Background: Cancer therapeutic vaccine induced cytotoxic T cell (CTL) responses are pivotal for the killing of tumour cells. Blocking interleukin 10 (IL-10) signalling at the time of immunization increases vaccine induced CTL responses and improves prevention of tumour growth in animal models compared to immunization without an IL-10 signalling blockade. Therefore, this immunization strategy may have potential to curtail cancer in a clinical setting. However, IL-10 deficiency leads to autoimmune disease in the gut. Blocking IL-10 at the time of immunization may result in unwanted side effects, especially immune-pathological diseases in the intestine. Methods: We investigated whether blocking IL-10 at the time of immunization results in intestinal inflammation responses in a mouse TC-1 tumour model and in a NOD autoimmune disease prone mouse model. Results: We now show that blocking IL-10 at the time of immunization increases IL-10 production by CD4+ T cells in the spleen and draining lymph nodes, and does not result in blood cell infiltration to the intestines leading to intestinal pathological changes. Moreover, immunization with papillomavirus like particles combined with simultaneously blocking IL-10 signalling does not increase the incidence of autoimmune disease in Non-obese diabetic (NOD) mice. Conclusions: Our results indicate that immunization with an IL-10 inhibitor may facilitate the generation of safe, effective therapeutic vaccines against chronic viral infection and cancer.

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Title: Blocking IL-10 signalling at the time of immunization does not increase unwanted side effects in mice
Authors: Guoying Ni (Author) - Griffith University
Zaowen Liao (Author) - First People's Hospital of Foshan, China
Shu Chen (Author) - First People's Hospital of Foshan, China
Tianfang Wang (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Jianwei Yuan (Author) - First Affiliated Hospital of Guangdong Pharmaceutical University, China
Xuan Pan (Author) - First Affiliated Hospital of Guangdong Pharmaceutical University, China
Kate E Mounsey (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Shelley F Cavezza (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Xiao Song Liu (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Ming Q Wei (Author) - Griffith University
Publication details: BMC Immunology, Vol.18, 40; 11
Publisher: BioMed Central Ltd.
Date published: 2017
DOI: 10.1186/s12865-017-0224-x
ISSN: 1471-2172
Copyright note: Copyright © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Organisation Unit: School of Health - Biomedicine; School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99450314402621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Immunology

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