Blocking IL-10 signalling at the time of immunization renders the tumour more accessible to T cell infiltration in mice

Shu Chen; Guoying Ni; Xiaolian Wu; Bin Zhu; Zaowen Liao; Yuejian Wang; Xiao Song Liu

doi:10.1016/j.cellimm.2015.11.002

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Blocking IL-10 signalling at the time of immunization renders the tumour more accessible to T cell infiltration in mice

Journal article

Peer reviewed

Blocking IL-10 signalling at the time of immunization renders the tumour more accessible to T cell infiltration in mice

Shu Chen, Guoying Ni, Xiaolian Wu, Bin Zhu, Zaowen Liao, Yuejian Wang and Xiao Song Liu

Cellular Immunology, Vol.300, pp.9-17

2016

DOI: https://doi.org/10.1016/j.cellimm.2015.11.002

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Abstract

IL-10 signalling blockade

immunization

T cell infiltration

We recently reported that blockade of IL-10 signalling at the time of a human papillomavirus (HPV) long E7 peptide/LPS immunization leads to the regression of established HPV-16 immortalized tumours in mice similar to that induced by long E7 peptide/incomplete Freund's adjuvant (IFA)-based vaccination. In this paper, we demonstrated that blockade of IL-10 signalling at the time of long E7 peptide/LPS could elicit stronger T cells responses and render the tumour more accessible for immune cell infiltration than vaccination with long E7 peptide/IFA. Furthermore, priming with long E7 peptide/LPS and IL10 signalling blockade then boosting with long E7 peptide/IFA elicits stronger CD8+ T cell responses than long E7 peptide/IFA immunization. The results suggest that priming with long E7 peptide/LPS and IL10 signalling inhibitor, then boosting with long E7 peptide/IFA elicits may lead to better HPV infection related tumour regression in clinic.

Details

Title: Blocking IL-10 signalling at the time of immunization renders the tumour more accessible to T cell infiltration in mice
Authors: Shu Chen (Author) - Foshan First People's Hospital, China
Guoying Ni (Author) - Griffith University
Xiaolian Wu (Author) - Foshan First People's Hospital, China
Bin Zhu (Author) - Foshan First People's Hospital, China
Zaowen Liao (Author) - Foshan First People's Hospital, China
Yuejian Wang (Author) - Foshan First People's Hospital, China
Xiao Song Liu (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Publication details: Cellular Immunology, Vol.300, pp.9-17
Publisher: Academic Press
Date published: 2016
DOI: 10.1016/j.cellimm.2015.11.002
ISSN: 0008-8749
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy
Language: English
Record Identifier: 99448909902621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Cell Biology; Immunology

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