Biocompatible porous titanium scaffolds produced using a novel space holder technique

Yunhui Chen; Jessica Ellen Frith; Ali Dehghan-Manshadi; Damon Kent; Michael Bermingham; Matthew Dargusch

doi:10.1002/jbm.b.34060

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Biocompatible porous titanium scaffolds produced using a novel space holder technique

Journal article

Peer reviewed

Biocompatible porous titanium scaffolds produced using a novel space holder technique

Yunhui Chen, Jessica Ellen Frith, Ali Dehghan-Manshadi, Damon Kent, Michael Bermingham and Matthew Dargusch

Journal of biomedical materials research. Part B, Applied biomaterials, Vol.106(8), pp.2796-2806

2018

DOI: https://doi.org/10.1002/jbm.b.34060

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Abstract

MG-63 cell culture

scaffolds

titanium

We describe a new fabrication strategy for production of porous titanium scaffolds for skeletal implants which provides a promising new approach to repair and remodel damaged bone tissue. The new strategy involves powder sintering of titanium powder, employing pharmaceutical sugar pellets as temporary space holders, to facilitate production of porous scaffolds with structures optimized for mechanical performance and osseointegration of implants. The spherical sugar pellets, with controlled size fractions and excellent biocompatibility, are easily removed by dissolution prior to sintering providing an ideal space holder material for controlled synthesis of titanium scaffolds with desired porosities and pore sizes. The scaffolds contain pores with high degrees of sphericity and interconnectivity which impart excellent mechanical properties and superior biocompatibility to the structures. Scaffolds with 40% porosity and a pore size range of 300-425 m exhibited an effective Young's modulus of 16.4±3.5 GPa and strength of 176±6 MPa, which closely mimics the properties of human bone, and were also able to support cell adhesion, viability and spreading in cell culture tests. Porous titanium scaffolds manufactured by this approach have excellent potential for hard tissue engineering applications.

Details

Title: Biocompatible porous titanium scaffolds produced using a novel space holder technique
Authors: Yunhui Chen (Corresponding Author) - University of Queensland
Jessica Ellen Frith (Author) - Monash University
Ali Dehghan-Manshadi (Author) - University of Queensland
Damon Kent (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Michael Bermingham (Author) - University of Queensland
Matthew Dargusch (Author) - University of Queensland
Publication details: Journal of biomedical materials research. Part B, Applied biomaterials, Vol.106(8), pp.2796-2806
Publisher: John Wiley & Sons Inc.
Date published: 2018
DOI: 10.1002/jbm.b.34060
ISSN: 1552-4973
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering
Language: English
Record Identifier: 99451484102621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Engineering, Biomedical; Materials Science, Biomaterials

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