Journal article
Bioactivity profiling of spider venoms reveals predominant hyaluronidase activities
Toxicon, Vol.269, pp.1-5
2026
PMID: 41274584
Abstract
Spider venoms are primarily composed of small neurotoxic peptides. However, recent studies suggested a hitherto overlooked diversity of spider venom enzymes, although their functional space still remains largely unexplored. We tested 10 spider venoms for enzymatic activities covering six enzyme classes and found that all tested enzymatic activities can be detected in at least some of the venoms and that hyaluronidases exhibit particularly high enzymatic activities. With this, our study provides functional evidence for the proposed biological significance of enzymes in spider venoms, but more detailed investigations are required.
Details
- Title
- Bioactivity profiling of spider venoms reveals predominant hyaluronidase activities
- Authors
- Josephine Dresler - Fraunhofer Institute for Molecular Biology and Applied EcologyVolker Herzig - University of the Sunshine Coast, Queensland, Centre for BioinnovationLennart Schulte - LOEWE Centre for Translational Biodiversity GenomicsTim Lüddecke (Corresponding Author) - Fraunhofer Institute for Molecular Biology and Applied Ecology
- Publication details
- Toxicon, Vol.269, pp.1-5
- Publisher
- Elsevier Ltd
- Date published
- 2026
- DOI
- 10.1016/j.toxicon.2025.108667
- ISSN
- 1879-3150
- PMID
- 41274584
- Copyright note
- © 2025 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Data Availability
- All data available as a supplement.
- Grant note
- The authors thank the German Arachnological Society (Deutsche Arachnologische Gesellschaft, DeArGe e.V.) for supporting this study via their young investigators grant awarded to J.D. We also thank the members of the DeArGe e.V. for providing access to the spiders to enable venom collections. T.L. and L.S were funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation, ref. 505696476).
- Organisation Unit
- School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 991184286902621
- Output Type
- Journal article
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- Pharmacology & Pharmacy
- Toxicology
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