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Bioactive Polyphenolic Compounds from Propolis of Tetragonula carbonaria in the Gibberagee Region1.22 MB
Published VersionCC BY V4.0, Open Access
Journal article
Bioactive Polyphenolic Compounds from Propolis of Tetragonula carbonaria in the Gibberagee Region, New South Wales, Australia
Foods, Vol.14(6), pp.1-16
2025
Abstract
Stingless bee propolis has emerged globally as a new source of bioactive molecules that can advance human health. However, limited research has been conducted on Australian stingless bee propolis. This study investigated the chemical composition and biological activity of the propolis produced by the stingless bees Tetragonula carbonaria from Gibberagee, a distinct region of New South Wales state in Australia. Using bioassay-guided fractionation, twelve compounds were isolated, including six A-ring methylated flavonoids. Nine of these compounds demonstrated strong scavenging activity against 2,2-diphenyl-1-picrylhydrazyl radicals, with five exhibiting greater potency than vitamin C. Chemical structures of seven additional minor flavonoids were determined through an intensive MS/MS data analysis. In silico screening of these 19 compounds revealed that all, except for gallic acid, displayed a higher binding affinity to α-glucosidase than the antidiabetic drug, voglibose. This study showed that the Gibberagee stingless bee propolis is a promising source for nutraceutical and cosmeceutical applications owing to its strong antioxidant and antidiabetic properties. The unique profile of A-ring C-methylated flavonoids potentially provides valuable insights into its botanical origin.
Details
- Title
- Bioactive Polyphenolic Compounds from Propolis of Tetragonula carbonaria in the Gibberagee Region, New South Wales, Australia
- Authors
- Dylan W. Ebner - University of the Sunshine Coast, Queensland, Centre for BioinnovationDamon C. Woods - University of the Sunshine Coast, Queensland, Centre for BioinnovationTrong D. Tran (Corresponding Author) - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
- Publication details
- Foods, Vol.14(6), pp.1-16
- Publisher
- MDPI AG
- Date published
- 2025
- DOI
- 10.3390/foods14060965
- ISSN
- 2304-8158
- Copyright note
- © 2025 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Data Availability
- The original contributions presented in this study are included in the article/Supplementary Materials. The original GNPS data can be found at the following links: Negative MS/MS data: https://gnps.ucsd.edu/ProteoSAFe/status.jsp?task=ee158423f09a4993b166ac837 c5d4204 (accessed on 15 August 2024). Positive MS/MS data: https://gnps.ucsd.edu/ProteoSAFe/ status.jsp?task=ee158423f09a4993b166ac837c5d4204 (accessed on 15 August 2024). Further inquiries can be directed to the corresponding author.
- Grant note
- We thank GCR Primary Industries Pty Ltd. for financial support. We acknowledge the Australian Research Council for support towards an NMR instrument (ARC LE140100119) and the UniSC GROW for support towards an uHPLC-QTOF MS system.
- Organisation Unit
- Academic Support Unit; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 991121752202621
- Output Type
- Journal article
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