Babesia bovis: Evidence for selection of subpopulations during attenuation

C A Carson; Peter Timms; A F Cowman; N P Stewart

doi:10.1016/0014-4894(90)90124-U

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Babesia bovis: Evidence for selection of subpopulations during attenuation

Journal article

Peer reviewed

Babesia bovis: Evidence for selection of subpopulations during attenuation

C A Carson, Peter Timms, A F Cowman and N P Stewart

Experimental Parasitology, Vol.70(4), pp.404-410

1990

DOI: https://doi.org/10.1016/0014-4894(90)90124-U

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Abstract

babesia bovis

protozoa

parasitic

babesiosis

bovine

virulence

attenuation process

subpopulations

vaccination

cattle

ticks

boophilus microplus

probes

radiolabeling

biosynthetic

electrophoresis

agarose

southern blotting

hybridization

DNA probes were used to detect variation in subpopulations of virulent and serially passaged Babesia bovis. Two distinct patterns were evident after hybridization to genomic DNA; the first was a basic profile typical of virulent B. bovis and the second, a more variable array, was characteristic of B. bovis after various stages of attenuation. Tick transmission of avirulent B. bovis causes reversion to the virulent genomic pattern, suggesting that selective enrichment of a small residual subpopulation caused reversion to a virulent profile of subpopulations. Certain genomic fragments, predominant in either virulent or avirulent parasite forms, are putative "markers" or actual elements responsible for these biological characteristics. © 1990.

Details

Title: Babesia bovis: Evidence for selection of subpopulations during attenuation
Authors: C A Carson (Author) - Department of Primary Industries
Peter Timms (Author) - Department of Primary Industries
A F Cowman (Author) - Department of Primary Industries
N P Stewart (Author) - Department of Primary Industries
Publication details: Experimental Parasitology, Vol.70(4), pp.404-410
Publisher: Academic Press
Date published: 1990
DOI: 10.1016/0014-4894(90)90124-U
ISSN: 0014-4894
Organisation Unit: University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99449890702621
Output Type: Journal article

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