Journal article
BDNF SNPs are implicated in comorbid alcohol dependence in schizophrenia but not in alcohol-dependent patients without schizophrenia
Alcohol and Alcoholism, Vol.49(5), pp.491-497
2014
PMID: 24993285
Abstract
Aims: The functional BDNF single nucleotide polymorphism (SNP) rs6265 has been associated with many disorders including schizophrenia and alcohol dependence. However, studies have been inconsistent, reporting both positive and negative associations. Comorbid alcohol dependence has a high prevalence in schizophrenia so we investigated the role of rs6265 in alcohol dependence in Australian populations of schizophrenia and alcohol-dependent patients. Methods: Two BDNF SNPs rs6265 and a nearby SNP rs7103411 were genotyped in a total of 848 individuals. These included a schizophrenia group (n = 157) and a second schizophrenia replication group (n = 235), an alcohol-dependent group (n = 231) that had no schizophrenia diagnosis and a group of healthy controls (n = 225). Results: Allelic association between rs7103411 and comorbid alcohol dependence was identified (P = 0.044) in the primary schizophrenia sample. In the replication study, we were able to detect allelic associations between both BDNF SNPs and comorbid alcohol dependence (rs6265, P = 0.006; rs7103411, P = 0.014). Moreover, we detected association between both SNPs and risk-taking behaviour after drinking (rs6265, P = 0.005; rs7103411, P = 0.009) and we detected strong association between both SNPs and alcohol dependence in males (rs6265, P = 0.009; rs7103411, P = 0.013) while females showed association with multiple behavioural measures reflecting repetitive alcohol consumption. Haplotype analysis revealed the rs6265-rs7103411 A/C haplotype is associated with comorbid alcohol dependence (P = 0.002). When these SNPs were tested in the non-schizophrenia alcohol-dependent group we were unable to detect association. Conclusion: We conclude that these BDNF SNPs play a role in development of comorbid alcohol dependence in schizophrenia while our data do not indicate that they play a role in alcohol-dependent patients who do not have schizophrenia.
Details
- Title
- BDNF SNPs are implicated in comorbid alcohol dependence in schizophrenia but not in alcohol-dependent patients without schizophrenia
- Authors
- Sern-Yih Cheah (Author) - Queensland University of TechnologyBruce R Lawford (Author) - Queensland University of TechnologyRoss Young (Author) - Queensland University of TechnologyJason P Connor (Author) - The University of QueenslandC Phillip Morris (Author) - Queensland University of TechnologyJoanne Voisey (Author) - Queensland University of Technology
- Publication details
- Alcohol and Alcoholism, Vol.49(5), pp.491-497
- Publisher
- Oxford University Press
- Date published
- 2014
- DOI
- 10.1093/alcalc/agu040
- ISSN
- 1464-3502; 0735-0414
- PMID
- 24993285
- Copyright note
- Copyright (c) 2014. This is a pre-copyedited, author-produced version of an article accepted for publication in Alcohol and Alcoholism following peer review. The version of record Sern-Yih Cheah, Bruce R. Lawford, Ross McD. Young, Jason P. Connor, C. Phillip Morris, Joanne Voisey, BDNF SNPs Are Implicated in Comorbid Alcohol Dependence in Schizophrenia But Not in Alcohol-Dependent Patients Without Schizophrenia, Alcohol and Alcoholism, Volume 49, Issue 5, September/October 2014, Pages 491–497, https://doi.org/10.1093/alcalc/agu040 is available online at: https://doi.org/10.1093/alcalc/agu040
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99551005302621
- Output Type
- Journal article
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