Axonal conduction in multiple sclerosis: A combined magnetic resonance imaging and electrophysiological study of the medial longitudinal fasciculus

C Wang; D Paling; L Chen; S N Hatton; Jim Lagopoulos; S T Aw; M C Kiernan; M H Barnett

doi:10.1177/1352458514556301

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Axonal conduction in multiple sclerosis: A combined magnetic resonance imaging and electrophysiological study of the medial longitudinal fasciculus

Journal article

Peer reviewed

Axonal conduction in multiple sclerosis: A combined magnetic resonance imaging and electrophysiological study of the medial longitudinal fasciculus

C Wang, D Paling, L Chen, S N Hatton, Jim Lagopoulos, S T Aw, M C Kiernan and M H Barnett

Multiple Sclerosis Journal, Vol.21(7), pp.905-915

2015

DOI: https://doi.org/10.1177/1352458514556301

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Abstract

multiple sclerosis

magnetic resonance imaging

electrophysiology

medial longitudinal fasciculus

demyelination

remyelination

axonal conduction

Objective: The objective of this paper is to inform the pathophysiology of medial longitudinal fasciculus (MLF) axonal dysfunction in patients with internuclear ophthalmoplegia (INO) due to multiple sclerosis (MS), and develop a composite structural-functional biomarker of axonal and myelin integrity in this tract. Methods: Eighteen patients with definite MS and clinically suspected INO underwent electrical vestibular stimulation and search-coil eye movement recording. Components of the electrically evoked vestibulo-ocular reflex (eVOR) were analyzed to probe the latency and fidelity of MLF axonal conduction. The MLF and T2-visible brainstem lesions were defined by high-resolution MRI. White matter integrity was determined by diffusion-weighted imaging metrics. Results: eVOR onset latency was positively correlated with MLF lesion length (left: r = 0.66, p = 0.004; right: r = 0.75, p = 0.001). The mean conduction velocity ±SD) within MLF lesions was estimated at 2.72 ±0.87) m/s. eVOR onset latency correlated with normalized axial diffusivity (r = 0.66, p < 0.001) and fractional anisotropy (r = 0.44, p = 0.02) after exclusion of cases with ipsilateral vestibular root entry zone lesions. Conclusions: Axonal conduction velocity through lesions involving the MLF was reduced below levels predicted for natively myelinated and remyelinated axons. Composite in vivo biomarkers enable delineation of axonal from myelin processes and may provide a crucial role in assessing efficacy of novel reparative therapies in MS. © The Author(s), 2014.

Details

Title: Axonal conduction in multiple sclerosis: A combined magnetic resonance imaging and electrophysiological study of the medial longitudinal fasciculus
Authors: C Wang (Author) - University of Sydney
D Paling (Author) - University of Sheffield, United Kingdom
L Chen (Author) - University of Sydney
S N Hatton (Author) - University of Sydney
Jim Lagopoulos (Author) - University of Sydney
S T Aw (Author) - University of Sydney
M C Kiernan (Author) - University of Sydney
M H Barnett (Author) - University of Sydney
Publication details: Multiple Sclerosis Journal, Vol.21(7), pp.905-915
Publisher: Sage Publications Ltd.
Date published: 2015
DOI: 10.1177/1352458514556301
ISSN: 1352-4585
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99449834202621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Clinical Neurology; Neurosciences

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