Autosomal linkage analysis for cannabis use behaviors in Australian adults

A Agrawal; K I Morley; N K Hansell; M L Pergadia; G W Montgomery; Dixie J Statham; R D Todd; P A F Madden; A C Heath; J Whitfield; N G Martin; M T Lynskey

doi:10.1016/j.drugalcdep.2008.05.009

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Autosomal linkage analysis for cannabis use behaviors in Australian adults

Journal article

Open access

Peer reviewed

Autosomal linkage analysis for cannabis use behaviors in Australian adults

A Agrawal, K I Morley, N K Hansell, M L Pergadia, G W Montgomery, Dixie J Statham, R D Todd, P A F Madden, A C Heath, J Whitfield, …

Drug and Alcohol Dependence, Vol.98(3), pp.185-190

2008

DOI: https://doi.org/10.1016/j.drugalcdep.2008.05.009

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Abstract

cannabis

linkage

Cannabis is the most commonly used illicit drug in developed and in developing nations. Twin studies have highlighted the role of genetic influences on early stages of cannabis use, such as a lifetime history of use, early-onset use and frequent use, however, we are not aware of any genomic studies that have examined these phenotypes. Using data on 2314 families consisting of 5600 adult Australian offspring and their parents, all of whom were scanned using 1399 unique autosomal markers, we conducted autosomal linkage analyses for lifetime history of cannabis initiation, early-onset cannabis use and frequency of use, using a variance components approach in the linkage package MERLIN. Suggestive evidence for linkage was found on chromosome 18 (LOD 2.14 for frequency of use, LOD 1.97 for initiation, at 90-97 cM) and also on chromosome 19 (LOD 1.92 for early-onset at 17 cM). These LOD scores did not meet genome-wide significance. Further replication of these linkage regions in other samples will be required, although these initial results suggest further targeted efforts on chromosome 18 may yield interesting candidate genes for early stages of cannabis-related behaviors.

Details

Title: Autosomal linkage analysis for cannabis use behaviors in Australian adults
Authors: A Agrawal (Author) - Washington University, United States
K I Morley (Author) - Queensland Institute of Medical Research
N K Hansell (Author) - Queensland Institute of Medical Research
M L Pergadia (Author) - Washington University, United States
G W Montgomery (Author) - Queensland Institute of Medical Research
Dixie J Statham (Author) - Queensland Institute of Medical Research
R D Todd (Author) - Washington University, United States
P A F Madden (Author) - Washington University, United States
A C Heath (Author) - Washington University, United States
J Whitfield (Author) - Queensland Institute of Medical Research
N G Martin (Author) - Queensland Institute of Medical Research
M T Lynskey (Author) - Washington University, United States
Publication details: Drug and Alcohol Dependence, Vol.98(3), pp.185-190
Publisher: Elsevier Ireland Ltd.
Date published: 2008
DOI: 10.1016/j.drugalcdep.2008.05.009
ISSN: 0376-8716
Organisation Unit: School of Social Sciences - Legacy; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99449772002621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Psychiatry; Substance Abuse

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Source: InCites