Journal article
Auditory event-related potentials in individuals with subjective and mild cognitive impairment
Behavioural Brain Research, Vol.391, pp.1-8
2020
PMID: 32446915
Abstract
Objective:
The analysis of event-related potentials (ERPs) is a useful tool to differentiate between healthy older adults, and individuals with mild cognitive impairment (MCI). Less is known about the ERPs’ sensitivity of differentiating between individuals with subjective cognitive impairment (SCI) and MCI, as early evidence indicates similar brain alterations between these two groups. In order, to establish tests that are sensitive to subclinical impairment, this study compared auditory evoked ERPs between individuals with SCI and MCI.
Methods:
Besides assessing cognitive performance in four neuropsychological tests (Trail Making Test A + B, verbal fluency letter and category task), latency and amplitude of ERP components evoked by an auditory oddball paradigm were compared between two groups of either individuals with SCI (n = 13) or MCI (n = 13).
Results:
While individuals with MCI performed significantly worse in all neuropsychological tests (TMT A: p = 0.001, Cohen’s d = 1.5; TMT B: p = 0.030, Cohen’s d = 0.94; verbal fluency letter: p = 0.0011, Cohen’s d = 1.08; verbal fluency category: p = 0.038; Cohen’s d = 0.86), no significant differences (p > 0.05) were found in ERP components with small to moderate effect sizes (Cohen’s d ranged between 0.11 – 0.59).
Conclusion:
ERPs evoked by an auditory oddball paradigm lack sensitivity to differentiate between individuals with SCI and MCI, although significant differences in cognitive performance were detected by neuropsychological tests. Similar pathophysiological brain alterations may limit utility of ERPs as indicated by previous research and results of this study. Cognitively more challenging tasks than the auditory oddball paradigm may be considered by future investigations.
Details
- Title
- Auditory event-related potentials in individuals with subjective and mild cognitive impairment
- Authors
- Tim Stuckenschneider (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - LegacyChristopher Askew (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - LegacyJan Weber (Author) - Eberhard-Karls-Universität TübingenVera Abeln (Author) - German Sport University CologneStefanie Rüdiger (Author) - University of QueenslandMathew J Summers (Author) - University of the Sunshine Coast, Queensland, School of Social Sciences - LegacyStefan Schneider (Author) - University of the Sunshine Coast
- Contributors
- NeuroExercise Study Group (Research Group)
- Publication details
- Behavioural Brain Research, Vol.391, pp.1-8
- Publisher
- Elsevier BV
- Date published
- 2020
- DOI
- 10.1016/j.bbr.2020.112700
- ISSN
- 1872-7549
- PMID
- 32446915
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health - Sports & Exercise Science; School of Health - Psychology; School of Health; School of Health and Behavioural Sciences - Legacy; School of Health and Sport Sciences - Legacy; School of Social Sciences - Legacy; Cancer Research Cluster
- Language
- English
- Record Identifier
- 99462908402621
- Output Type
- Journal article
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