Journal article
Attention-deficit/hyperactivity disorder: Neurophysiology, information processing, arousal and drug development
Expert Review of Neurotherapeutics, Vol.6(11), pp.1721-1734
2006
Abstract
In this review, we draw on literature from both animal and human neurophysiological studies to consider the neurochemical mechanisms underlying attention-deficit/hyperactivity disorder (ADHD). Psychophysiological and neuropsychological research is used to propose possible etiological endophenotypes of ADHD. These are conceptualized as patients with distinct cortical-arousal, information-processing or maturational abnormalities, or a combination thereof, and how the endophenotypes can be used to help drug development and optimize treatment and management. To illustrate, the paper focuses on neuro- and psychophysiological evidence that suggests cholinergic mechanisms may underlie specific information-processing abnormalities that occur in ADHD. The clinical implications for a cholinergic hypothesis of ADHD are considered, along with its possible implications for treatment and pharmacological development. © 2006 Future Drugs Ltd.
Details
- Title
- Attention-deficit/hyperactivity disorder: Neurophysiology, information processing, arousal and drug development
- Authors
- D L Rowe (Author) - University of SydneyDaniel F Hermens (Author) - University of Sydney
- Publication details
- Expert Review of Neurotherapeutics, Vol.6(11), pp.1721-1734
- Publisher
- Taylor & Francis Ltd.
- Date published
- 2006
- DOI
- 10.1586/14737175.6.11.1721
- ISSN
- 1473-7175
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99451268402621
- Output Type
- Journal article
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