Associations between Maternal Nutrition and the Concentrations of Human Milk Oligosaccharides in a Cohort of Healthy Australian Lactating Women

Caren Biddulph; Mark Holmes; Trong D. Tran; Anna Kuballa; Peter S. W. Davies; Pieter Koorts; Judith Maher

doi:10.3390/nu15092093

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Associations between Maternal Nutrition and the Concentrations of Human Milk Oligosaccharides in a Cohort of Healthy Australian Lactating Women

Journal article

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Peer reviewed

Associations between Maternal Nutrition and the Concentrations of Human Milk Oligosaccharides in a Cohort of Healthy Australian Lactating Women

Caren Biddulph, Mark Holmes, Trong D. Tran, Anna Kuballa, Peter S. W. Davies, Pieter Koorts and Judith Maher

Nutrients, Vol.15(9), pp.1-14

2023

DOI: https://doi.org/10.3390/nu15092093

PMCID: PMC10180645

PMID: 37432220

Appears in UniSC Diversity and Inclusion Research Collection

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Abstract

body composition

breastfeeding

human milk oligosaccharide

lactation

maternal diet

UniSC Diversity Area - Life Stages

Human milk oligosaccharides (HMOs) are complex glycans associated with positive infant health outcomes. The concentrations of HMOs in the milk of lactating women are associated with substantial intra- and inter-individual differences and may be influenced by maternal physiological and/or nutrition-related factors. The primary aim of this study was to explore potential influences of short-term maternal diet and current body composition on HMO profiles in mature human milk. Milk samples were collected at 3–4 months postpartum from 101 healthy Australian women using standardised procedures, and analysed for macronutrients (lactose, fat, and protein). In addition, HMO concentrations were analysed using liquid-chromatography mass-spectrometry (LC-MS). Maternal dietary data were collected using three validated 24-h dietary recalls, and the body composition of a subgroup of mothers was assessed by DEXA scans (n = 30). Most (79%) of the women were secretor-positive. Individual nutrients were not significantly correlated with HMO concentrations after correction for multiple comparisons (p > 0.05), except for dietary folate intake. DEXA scans revealed no associations between HMO profiles and maternal body composition during established lactation. The study findings suggest a lack of clear and consistent associations between maternal nutrition and HMO concentrations in mature human milk from healthy lactating women with adequate dietary intake. The prevailing influence of genetic variation in lactating mothers may overshadow any impact of maternal nutritional and/or physiological status on HMO composition in mature human milk.

Details

Title: Associations between Maternal Nutrition and the Concentrations of Human Milk Oligosaccharides in a Cohort of Healthy Australian Lactating Women
Authors: Caren Biddulph (Corresponding Author) - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Mark Holmes (Author) - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Trong D. Tran (Author) - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Anna Kuballa (Author) - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Peter S. W. Davies (Author) - The University of Queensland
Pieter Koorts (Author) - Royal Brisbane and Women's Hospital
Judith Maher (Author) - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Publication details: Nutrients, Vol.15(9), pp.1-14
Publisher: MDPI AG
Date published: 2023
DOI: 10.3390/nu15092093
ISSN: 2072-6643
PMID: 37432220; PMC10180645
Copyright note: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Grant note: Caren Biddulph is a recipient of the Research Training Program (RTP) Stipend Scholarship, funded by the Australian Government and UniSC, and the Agilent Technologies Top-up/Sunshine Coast Research Scholarship (USCRS). HMO standards were donated by Glycom A/S, a DSM group company (Denmark). Publication was supported by the Centre for Bioinnovation, UniSC, Australia.
Organisation Unit: School of Health - Biomedicine; School of Health; School of Health - Nutrition & Dietetics; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99725552302621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Nutrition & Dietetics

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