Association of the microRNA-Single Nucleotide Polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: A case control study

A Upadhyaya; R A Smith; D Chacon-Cortes; G Revêchon; C Bellis; R A Lea; L M Haupt; S K Chambers; Philippa H Youl; L R Griffiths

doi:10.1016/j.gene.2015.10.019

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Association of the microRNA-Single Nucleotide Polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: A case control study

Journal article

Open access

Peer reviewed

Association of the microRNA-Single Nucleotide Polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: A case control study

A Upadhyaya, R A Smith, D Chacon-Cortes, G Revêchon, C Bellis, R A Lea, L M Haupt, S K Chambers, Philippa H Youl and L R Griffiths

Gene, Vol.576(1, Part 2), pp.256-260

2016

DOI: https://doi.org/10.1016/j.gene.2015.10.019

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Abstract

miR146a

polymorphism

breast cancer

BRCA

SNP

miRNA

BACKGROUND: Breast cancer (BC) is primarily considered a genetic disorder with a complex interplay of factors including age, gender, ethnicity, family history, personal history and lifestyle with associated hormonal and non-hormonal risk factors. The SNP rs2910164 in miR146a (a G to C polymorphism) was previously associated with increased risk of BC in cases with at least a single copy of the C allele in breast cancer, though results in other cancers and populations have shown significant variation. METHODS: In this study, we examined this SNP in an Australian sporadic breast cancer population of 160 cases and matched controls, with a replicate population of 403 breast cancer cases using High Resolution Melting. RESULTS: Our analysis indicated that the rs2910164 polymorphism is associated with breast cancer risk in both primary and replicate populations (p=0.03 and 0.0013, respectively). In contrast to the results of familial breast cancer studies, however, we found that the presence of the G allele of rs2910164 is associated with increased cancer risk, with an OR of 1.77 (95% CI 1.40-2.23). CONCLUSIONS: The microRNA miR146a has a potential role in the development of breast cancer and the effects of its SNPs require further inquiry to determine the nature of their influence on breast tissue and cancer. Copyright © 2015 Elsevier B.V. All rights reserved.

Details

Title: Association of the microRNA-Single Nucleotide Polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: A case control study
Authors: A Upadhyaya (Author) - Queensland University of Technology
R A Smith (Author) - Queensland University of Technology
D Chacon-Cortes (Author) - Queensland University of Technology
G Revêchon (Author) - Queensland University of Technology
C Bellis (Author) - Queensland University of Technology
R A Lea (Author) - Queensland University of Technology
L M Haupt (Author) - Queensland University of Technology
S K Chambers (Author) - Griffith University
Philippa H Youl (Author) - Griffith University
L R Griffiths (Author) - Queensland University of Technology
Publication details: Gene, Vol.576(1, Part 2), pp.256-260
Publisher: Elsevier BV
Date published: 2016
DOI: 10.1016/j.gene.2015.10.019
ISSN: 0378-1119
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
Language: English
Record Identifier: 99450593202621
Output Type: Journal article

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Web Of Science research areas: Genetics & Heredity

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