Association of the UCP polymorphisms with susceptibility to obesity: Case-control study and meta-analysis

L De Almeida Brondani; B M De Souza; T S Assmann; A P Bouças; A C Bauer; L H Canani; D Crispim

doi:10.1007/s11033-014-3371-7

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Association of the UCP polymorphisms with susceptibility to obesity: Case-control study and meta-analysis

Journal article

Peer reviewed

Association of the UCP polymorphisms with susceptibility to obesity: Case-control study and meta-analysis

L De Almeida Brondani, B M De Souza, T S Assmann, A P Bouças, A C Bauer, L H Canani and D Crispim

Molecular Biology Reports, Vol.41(8), pp.5053-5067

2014

DOI: https://doi.org/10.1007/s11033-014-3371-7

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Abstract

uncoupling proteins

genetic polymorphisms

obesity

meta-analysis

This paper describes a case-control study and a meta-analysis performed to evaluate if the following polymorphisms are associated with presence of obesity: -3826A/G (UCP1); -866G/A, Ala55Val and Ins/Del (UCP2) and -55C/T (UCP3). The case-control study enrolled 282 obese and 483 non-obese patients with type 2 diabetes. A literature search was made to identify all studies that evaluated associations between UCP1-3 polymorphisms and obesity. In the case-control study the distributions of the UCP variants did not differ between obese and non-obese groups (P > 0.05). Forty-seven studies were eligible for the meta-analysis and the results showed that the UCP2 -866G/A and UCP3 -55C/T polymorphisms were associated with protection to obesity in Europeans (OR = 0.89, 95 % CI 0.82-0.97 and OR = 0.88, 95 % CI 0.80-0.97, respectively). The UCP2 Ala55 val polymorphism was associated with obesity in Asians (OR = 1.61, 95 % CI 1.13-2.30). The UCP2 Ins/Del polymorphism was associated with obesity mainly in Europeans (OR = 1.19, 95 % CI 1.00-1.42). There was no significant association of the UCP1 -3826A/G polymorphism with obesity. In our case-control study we were not able to demonstrate any association between UCP polymorphisms and obesity in T2DM patients; however, in the meta-analysis we detected a significant association of UCP2 -866G/A, Ins/Del, Ala55Val and UCP3 -55C/T polymorphisms with obesity.

Details

Title: Association of the UCP polymorphisms with susceptibility to obesity: Case-control study and meta-analysis
Authors: L De Almeida Brondani (Author) - Universidade Federal do Rio Grande do Sul, Brazil
B M De Souza (Author) - Universidade Federal do Rio Grande do Sul, Brazil
T S Assmann (Author) - Universidade Federal do Rio Grande do Sul, Brazil
A P Bouças (Author) - Universidade Federal do Rio Grande do Sul, Brazil
A C Bauer (Author) - Hospital de Clinicas de Porto Alegre, Brazil
L H Canani (Author) - Universidade Federal do Rio Grande do Sul, Brazil
D Crispim (Author) - Universidade Federal do Rio Grande do Sul, Brazil
Publication details: Molecular Biology Reports, Vol.41(8), pp.5053-5067
Publisher: Springer Netherlands
Date published: 2014
DOI: 10.1007/s11033-014-3371-7
ISSN: 0301-4851
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99451376402621
Output Type: Journal article

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Web Of Science research areas: Biochemistry & Molecular Biology

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