Association of the D2 dopamine receptor A1 allele with alcoholism: Medical severity of alcoholism and type of controls

Bruce R Lawford; Ross Young; John A Rowell; John N Gibson; G.F.X Feeney; Terry L Ritchie; Karl Syndulko; Ernest P Noble

doi:10.1016/S0006-3223(96)00478-7

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Association of the D2 dopamine receptor A1 allele with alcoholism: Medical severity of alcoholism and type of controls

Journal article

Peer reviewed

Association of the D2 dopamine receptor A1 allele with alcoholism: Medical severity of alcoholism and type of controls

Bruce R Lawford, Ross Young, John A Rowell, John N Gibson, G.F.X Feeney, Terry L Ritchie, Karl Syndulko and Ernest P Noble

Biological Psychiatry, Vol.41(4), pp.386-393

1997

DOI: https://doi.org/10.1016/S0006-3223(96)00478-7

PMID: 9034533

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https://doi.org/10.1016/S0006-3223(96)00478-7View

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Abstract

Alcoholism

D2 dopamine receptor gene

medical severity

A1 allele

control types

D 2 dopamine receptor (DRD2) A1 allele frequency was determined in alcoholics of varying medical severity from three different inpatient settings and in various controls. A1 frequency was .15 in 68 alcoholics in a detoxification unit (group A), .19 in 90 alcoholics in a rehabilitation unit (group B), and .31 in 43 alcoholics in a gastroenterology unit (group C). Group C had a higher Al frequency than group B (p = .045) or group A (p = .005) alcoholics. In 46 controls (group D), A1 frequency was. 18. In subsets" of these controls, A1 frequency was • 14 in 39 subjects with a negative family history. (FH-) of alcoholism (group E), .06 in 34 subjects without previous hazardous alcohol consumption (group F), and .05 in 30 subjects with F Hand without previous hazardous alcohol consumption (group G). A1 frequency was significantly higher in group C alcoholics than group F (p = .0002) or group G (p = .0002) controls; however, no A1 frequency difference was found among group A alcoholics and any of the control groups. The severity of alcoholism and the type of controls used are important determinants of DRD2 A1 allele association with alcoholism.

Details

Title: Association of the D2 dopamine receptor A1 allele with alcoholism: Medical severity of alcoholism and type of controls
Authors: Bruce R Lawford (Author) - University of Queensland
Ross Young (Author) - University of Queensland
John A Rowell (Author) - Royal Brisbane Hospital
John N Gibson (Author) - Greenslopes Private Hospital
G.F.X Feeney (Author) - Princess Alexandra Hospital
Terry L Ritchie (Author) - University of California Los Angeles
Karl Syndulko (Author)
Ernest P Noble (Author) - University of California Los Angeles
Publication details: Biological Psychiatry, Vol.41(4), pp.386-393
Publisher: Elsevier Inc.
DOI: 10.1016/S0006-3223(96)00478-7
ISSN: 1873-2402
PMID: 9034533
Organisation Unit: University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
Language: English
Record Identifier: 99551005502621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Neurosciences; Psychiatry

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