Association of microRNA 17–92 cluster host gene (MIR17HG) polymorphisms with breast cancer

D Chacon-Cortes; R A Smith; R A Lea; Philippa H Youl; L R Griffiths

doi:10.1007/s13277-015-3200-1

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Association of microRNA 17–92 cluster host gene (MIR17HG) polymorphisms with breast cancer

Journal article

Peer reviewed

Association of microRNA 17–92 cluster host gene (MIR17HG) polymorphisms with breast cancer

D Chacon-Cortes, R A Smith, R A Lea, Philippa H Youl and L R Griffiths

Tumor Biology, Vol.36(7), pp.5369-5376

2015

DOI: https://doi.org/10.1007/s13277-015-3200-1

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Abstract

association analysis

breast cancer

haplotype

microRNA

single nucleotide polymorphisms (SNP)

Breast cancer incidence and mortality rates are increasing despite our current knowledge on the disease. Ninety-five percent of breast cancer cases correspond to sporadic forms of the disease and are believed to involve an interaction between environmental and genetic determinants. The microRNA 17-92 cluster host gene (MIR17HG) has been shown to regulate expression of genes involved in breast cancer development and progression. Study of single-nucleotide polymorphisms (SNPs) located in this cluster gene could help provide a further understanding of its role in breast cancer. Therefore, this study investigated six SNPs in the MIR17HG using two independent Australian Caucasian case-control populations (GRC-BC and GU-CCQ BB populations) to determine association to breast cancer susceptibility. Genotyping was undertaken using chip-based matrix assisted laser desorption ionisation time-of-flight (MALDI-TOF) mass spectrometry (MS). We found significant association between rs4824505 and breast cancer at the allelic level in both study cohorts (GRC-BC p = 0.01 and GU-CCQ BB p = 0.03). Furthermore, haplotypic analysis of results from our combined population determined a significant association between rs4824505/rs7336610 and breast cancer susceptibility (p = 5 × 10-4). Our study is the first to show that the A allele of rs4824505 and the AC haplotype of rs4824505/rs7336610 are associated with risk of breast cancer development. However, definitive validation of this finding requires larger cohorts or populations in different ethnical backgrounds. Finally, functional studies of these SNPs could provide a deeper understanding of the role that MIR17HG plays in the pathophysiology of breast cancer. © 2015, International Society of Oncology and BioMarkers (ISOBM).

Details

Title: Association of microRNA 17–92 cluster host gene (MIR17HG) polymorphisms with breast cancer
Authors: D Chacon-Cortes (Author) - Queensland University of Technology
R A Smith (Author) - Queensland University of Technology
R A Lea (Author) - Queensland University of Technology
Philippa H Youl (Author) - Griffith University
L R Griffiths (Author) - Queensland University of Technology
Publication details: Tumor Biology, Vol.36(7), pp.5369-5376
Publisher: Springer Netherlands
Date published: 2015
DOI: 10.1007/s13277-015-3200-1
ISSN: 1010-4283
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
Language: English
Record Identifier: 99450586602621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Oncology

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