Association of heparan sulfate proteoglycans SDC1 and SDC4 polymorphisms with breast cancer in an Australian Caucasian population

R K Okolicsanyi; A Buffiere; J M E Jacinto; D Chacon-Cortes; S K Chambers; Philippa H Youl; L M Haupt; L R Griffiths

doi:10.1007/s13277-014-2774-3

Back

Association of heparan sulfate proteoglycans SDC1 and SDC4 polymorphisms with breast cancer in an Australian Caucasian population

Journal article

Peer reviewed

Association of heparan sulfate proteoglycans SDC1 and SDC4 polymorphisms with breast cancer in an Australian Caucasian population

R K Okolicsanyi, A Buffiere, J M E Jacinto, D Chacon-Cortes, S K Chambers, Philippa H Youl, L M Haupt and L R Griffiths

Tumor Biology, Vol.36(3), pp.1731-1738

2015

DOI: https://doi.org/10.1007/s13277-014-2774-3

Files and links (1)

url

https://doi.org/10.1007/s13277-014-2774-3View

Published Version

Abstract

HSPG

syndecan

breast cancer

SNP

Breast cancer is a common disease in both developing and developed countries with early identification and treatment improving prognosis and survival. Heparan sulfate proteoglycans (HSPGs) are key components of the extracellular matrix (ECM) that mediate cell adhesion, motility, proliferation, invasion and cell signalling. Members of the syndecan family of HSPGs have been identified to be involved in breast cancer progression through their varied interactions with a number of growth factors, ligands and receptors. Specifically, high expression levels of syndecan-1 (SDC1) have been demonstrated in more invasive breast tumours while elevated syndecan-4 (SDC4) levels have been identified to correspond with improved prognosis. With genetic changes in the syndecans and their association with breast cancers plausible, we examined two single nucleotide polymorphisms in SDC1 (rs1131351) and SDC4 (rs67068737) within an Australian Caucasian breast cancer case/control population. No association was found with SDC4 and breast cancer in our population. However, a significant association between SDC1 and breast cancer was identified in both our case/control population and in a replication cohort. When both populations were combined for analysis, this association became more significant (genotype, p = 0.0003; allele, p = 0.0001). This data suggests an increased risk of developing breast cancer associated with the presence of the C allele of the SDC1 rs1131351 single nucleotide polymorphism (SNP) and may provide a marker toward early breast cancer detection. © 2014, International Society of Oncology and BioMarkers (ISOBM).

Details

Title: Association of heparan sulfate proteoglycans SDC1 and SDC4 polymorphisms with breast cancer in an Australian Caucasian population
Authors: R K Okolicsanyi (Author) - Queensland University of Technology
A Buffiere (Author) - AgroSup Dijon, France
J M E Jacinto (Author) - Queensland University of Technology
D Chacon-Cortes (Author) - Queensland University of Technology
S K Chambers (Author) - Edith Cowan University
Philippa H Youl (Author) - Queensland University of Technology
L M Haupt (Author) - Queensland University of Technology
L R Griffiths (Author) - Queensland University of Technology
Publication details: Tumor Biology, Vol.36(3), pp.1731-1738
Publisher: Springer Netherlands
Date published: 2015
DOI: 10.1007/s13277-014-2774-3
ISSN: 1010-4283
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
Language: English
Record Identifier: 99450414602621
Output Type: Journal article

Metrics

478 Record Views

12 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Oncology

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites