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Accepted VersionCC BY-NC-ND V4.0, Open Access
Journal article
Association of NOS1AP variants and depression phenotypes in schizophrenia
Journal of Affective Disorders, Vol.188, pp.263-269
2015
PMID: 26384012
Abstract
The nitric oxide synthase 1 adaptor protein gene (NOS1AP) has previously been recognised as a schizophrenia susceptibility gene due to its role in glutamate neurotransmission. The gene is believed to inhibit nitric oxide (NO) production activated by the N-methyl-d-aspartate (NMDA) receptor and reduced NO levels have been observed in schizophrenia patients. However, association studies investigating NOS1AP and schizophrenia have produced inconsistent results, most likely because schizophrenia is a clinically heterogeneous disorder. This study aims to investigate the association between NOS1AP variants and defined depression phenotypes of schizophrenia.
Nine NOS1AP SNPs, rs1415259, rs1415263, rs1858232, rs386231, rs4531275, rs4656355, rs4657178, rs6683968 and rs6704393 were genotyped in 235 schizophrenia subjects screened for various phenotypes of depression.
One NOS1AP SNP (rs1858232) was associated with the broad diagnosis of schizophrenia and eight SNPs were associated with depression related phenotypes within schizophrenia. The rs1415259 SNP showed strong association with sleep dysregulation phenotypes of depression.
Results suggest that NOS1AP variants are associated with various forms of depression in schizophrenia and are more prevalent in males.
Schizophrenia is a clinically heterogeneous disease that can vary greatly between different ethnic and geographic populations so our observations should be viewed with caution until they are independently replicated, particularly in larger patient cohorts.
•NOS1AP is proposed to be associated with depression phenotypes in schizophrenia.•We examined the association between nine NOS1AP SNPs and depression phenotypes in schizophrenia.•Eight SNPs were associated with depression phenotypes and were more prevalent in males.•One of the eight SNPs showed strong association with sleep-related depression phenotypes.
Details
- Title
- Association of NOS1AP variants and depression phenotypes in schizophrenia
- Authors
- Sern-Yih Cheah (Author) - Queensland University of TechnologyBruce R Lawford (Author) - Queensland University of TechnologyRoss Young (Author) - Queensland University of TechnologyC. Phillip Morris (Author) - Queensland University of TechnologyJoanne Voisey (Author) - Queensland University of Technology
- Publication details
- Journal of Affective Disorders, Vol.188, pp.263-269
- Publisher
- Elsevier BV
- Date published
- 2015
- DOI
- 10.1016/j.jad.2015.08.069
- ISSN
- 1573-2517; 0165-0327
- PMID
- 26384012
- Copyright note
- Copyright © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99551005602621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Clinical Neurology
- Psychiatry
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