Association between lifetime depression history, hippocampal volume and memory in non‐amnestic mild cognitive impairment

Isabella Hoi Kei Leung; Kathryn Mary Broadhouse; Loren Mowszowski; Haley M LaMonica; Jake Robert Palmer; Ian B Hickie; Sharon L Naismith; Shantel Leigh Duffy

doi:10.1111/ejn.15207

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Association between lifetime depression history, hippocampal volume and memory in non‐amnestic mild cognitive impairment

Journal article

Open access

Peer reviewed

Association between lifetime depression history, hippocampal volume and memory in non‐amnestic mild cognitive impairment

Isabella Hoi Kei Leung, Kathryn Mary Broadhouse, Loren Mowszowski, Haley M LaMonica, Jake Robert Palmer, Ian B Hickie, Sharon L Naismith and Shantel Leigh Duffy

European Journal of Neuroscience, Vol.54(3), pp.4953-4970

2021

DOI: https://doi.org/10.1111/ejn.15207

PMID: 33765347

Appears in UniSC Diversity and Inclusion Research Collection

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Abstract

antidepressive agents

cognitive dysfunction

depression

hippocampus

memory

UniSC Diversity Area - Disability and Inclusion

Hippocampal subfield volume loss in older adults with amnestic mild cognitive impairment (aMCI) and depression history are associated with amyloid beta and tau pathology, thereby increasing the risk for Alzheimer's disease (AD). However, no studies have exclusively examined distinct alterations in hippocampal subfields in non-amnestic MCI (naMCI) in relation to depression history. Here, we used both longitudinal and transverse hippocampal segmentation methods using the automated FreeSurfer software to examine whether a lifetime depression history is associated with differences in hippocampal head/body/tail (H/B/T) and key subfield volumes (CA1, subiculum, dentate gyrus) in older adults with naMCI. Further, we explored whether differences in hippocampal H/B/T and subfield volumes were associated with structured and unstructured verbal encoding and retention, comparing those with and without a depression history. The naMCI with a depression history group demonstrated larger or relatively preserved right CA1 volumes, which were associated with better unstructured verbal encoding and as well as structured verbal memory retention. This association between memory encoding and hippocampal CA1 and total head volume was significantly different to those with no depression history. The relationship between right CA1 volume and memory retention was also moderated by depression history status F (5,143) = 7.84, p < 0.001, R2 = 0.22. Those participants taking antidepressants had significantly larger hippocampal subiculum (p = 0.008), and right hippocampal body (p = 0.004) and better performance on structured encoding (p = 0.011) and unstructured memory retention (p = 0.009). These findings highlight the importance of lifetime depression history and antidepressant use on the hippocampus and encoding and memory retention in naMCI.

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Title: Association between lifetime depression history, hippocampal volume and memory in non‐amnestic mild cognitive impairment
Authors: Isabella Hoi Kei Leung (Author) - The University of Sydney
Kathryn Mary Broadhouse (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - Legacy
Loren Mowszowski (Corresponding Author) - The University of Sydney
Haley M LaMonica (Author) - The University of Sydney
Jake Robert Palmer (Author) - The University of Sydney
Ian B Hickie (Author) - The University of Sydney
Sharon L Naismith (Author) - The University of Sydney
Shantel Leigh Duffy (Author) - The University of Sydney
Publication details: European Journal of Neuroscience, Vol.54(3), pp.4953-4970
Publisher: Wiley-Blackwell Publishing Ltd.
Date published: 2021
DOI: 10.1111/ejn.15207
ISSN: 1460-9568
PMID: 33765347
Copyright note: This is the peer reviewed version of the following article: Leung, IHK, Broadhouse, KM, Mowszowski, L, et al. Association between lifetime depression history, hippocampal volume and memory in non-amnestic mild cognitive impairment. Eur J Neurosci. 2021; 54: 4953– 4970. https://doi.org/10.1111/ejn.15207, which has been published in final form at https://doi.org/10.1111/ejn.15207. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
Organisation Unit: School of Science and Engineering - Legacy; School of Health - Nursing; School of Education and Tertiary Access; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Thompson Institute; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99522208202621
Output Type: Journal article

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Web Of Science research areas: Neurosciences

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