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Assessment of the Emerging Threat Posed by Perfluoroalkyl and Polyfluoroalkyl Substances to Male Reproduction in Humans3.72 MB
Published VersionCC BY V4.0, Open Access
Journal article
Assessment of the Emerging Threat Posed by Perfluoroalkyl and Polyfluoroalkyl Substances to Male Reproduction in Humans
Frontiers in Endocrinology, Vol.12, pp.1-21
2022
PMID: 35356147
Abstract
Per-fluoroalkyl and polyfluoroalkyl substances (PFAS) are a diverse group of synthetic fluorinated chemicals used widely in industry and consumer products. Due to their extensive use and chemical stability, PFAS are ubiquitous environmental contaminants and as such, form an emerging risk factor for male reproductive health. The long half-lives of PFAS is of particular concern as the propensity to accumulate in biological systems prolong the time taken for excretion, taking years in many cases. Accordingly, there is mounting evidence supporting a negative association between PFAS exposure and an array of human health conditions. However, inconsistencies among epidemiological and experimental findings have hindered the ability to definitively link negative reproductive outcomes to specific PFAS exposure. This situation highlights the requirement for further investigation and the identification of reliable biological models that can inform health risks, allowing sensitive assessment of the spectrum of effects of PFAS exposure on humans. Here, we review the literature on the biological effects of PFAS exposure, with a specific focus on male reproduction, owing to its utility as a sentinel marker of general health. Indeed, male infertility has increasingly been shown to serve as an early indicator of a range of co-morbidities such as coronary, inflammatory, and metabolic diseases. It follows that adverse associations have been established between PFAS exposure and the incidence of testicular dysfunction, including pathologies such as testicular cancer and a reduction in semen quality. We also give consideration to the mechanisms that render the male reproductive tract vulnerable to PFAS mediated damage, and discuss novel remediation strategies to mitigate the negative impact of PFAS contamination and/or to ameliorate the PFAS load of exposed individuals.
Details
- Title
- Assessment of the Emerging Threat Posed by Perfluoroalkyl and Polyfluoroalkyl Substances to Male Reproduction in Humans
- Authors
- Leah Calvert (Author) - University of Newcastle AustraliaMark P Green (Author) - The University of MelbourneGeoffry N De Iuliis (Author) - University of Newcastle AustraliaMatthew D Dun (Author) - University of Newcastle AustraliaBrett D Turner (Author) - University of Technology SydneyBradley Clarke (Author) - The University of MelbourneAndrew Eamens (Author) - University of Newcastle AustraliaShaun D Roman (Author) - University of Newcastle AustraliaBrett Nixon (Author) - University of Newcastle Australia
- Publication details
- Frontiers in Endocrinology, Vol.12, pp.1-21
- Publisher
- Frontiers Research Foundation
- Date published
- 2022
- DOI
- 10.3389/fendo.2021.799043
- ISSN
- 1664-2392
- PMID
- 35356147
- Copyright note
- Copyright © 2022 Calvert, Green, De Iuliis, Dun, Turner, Clarke, Eamens, Roman and Nixon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99656594102621
- Output Type
- Journal article
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- Endocrinology & Metabolism
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