Assessment of ethnic variation in serum levels of total, complexed and free prostate specific antigen. Comparison of Maori, Pacific Island and New Zealand European populations

Marion Gray; B Delahunt; J Fowles; R Jefferson; P Weinstein; R Cooke; J Nacey

doi:10.1080/00313020310001619091

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Assessment of ethnic variation in serum levels of total, complexed and free prostate specific antigen. Comparison of Maori, Pacific Island and New Zealand European populations

Journal article

Peer reviewed

Assessment of ethnic variation in serum levels of total, complexed and free prostate specific antigen. Comparison of Maori, Pacific Island and New Zealand European populations

Marion Gray, B Delahunt, J Fowles, R Jefferson, P Weinstein, R Cooke and J Nacey

Pathology, Vol.35(6), pp.480-483

2003

DOI: https://doi.org/10.1080/00313020310001619091

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Abstract

Clinical Sciences

prostate

specific antigen

tPSA

cPSA

%fPSA

reference range

ethnic variation

Maori

Pacific Island

New Zealand European

Aims: To determine whether age-adjusted levels of serum total (tPSA) and complexed (cPSA) prostate specific antigen and the ratio of free to tPSA (%fPSA) differ by ethnic group independent of symptomatic disease. Methods: The serum levels of tPSA, cPSA, and %fPSA in relation to age, ethnicity and obstructive urinary symptoms were examined in 1405 Maori, Pacific Island and New Zealand European men in the Wellington region of New Zealand, and indicative reference range estimates produced. Participants were non-randomly selected from two study populations. Results: tPSA and cPSA increased with age while %fPSA decreased with age in all ethnic groups. Maori showed higher tPSA values in the 60-69 age group than other ethnic groups. cPSA increased more rapidly with age in Maori than in New Zealand Europeans or Pacific Islanders. %fPSA differed according to age across all three ethnic groups. The median and 5th percentile Pacific Island %fPSA values were higher in comparison to the %fPSA reference ranges of all other ethnic groups and were also higher than those reported in other studies. Once adjusted for urinary symptom score, only %fPSA in Pacific Island subjects remained significantly higher than that in New Zealand Europeans (P≤0.001). Conclusions: Our study indicates that %fPSA differs by ethnicity independent of symptomatic prostate disease.

Details

Title: Assessment of ethnic variation in serum levels of total, complexed and free prostate specific antigen. Comparison of Maori, Pacific Island and New Zealand European populations
Authors: Marion Gray (Author) - University of Otago, New Zealand
B Delahunt (Author) - University of Otago, New Zealand
J Fowles (Author) - Institute of Environmental Science and Research, New Zealand
R Jefferson (Author) - University of Otago, New Zealand
P Weinstein (Author) - University of Otago, New Zealand
R Cooke (Author) - Capital & Coast District Health Board, New Zealand
J Nacey (Author) - University of Otago, New Zealand
Publication details: Pathology, Vol.35(6), pp.480-483
Publisher: Lippincott Williams & Wilkins Ltd.
Date published: 2003
DOI: 10.1080/00313020310001619091
ISSN: 0031-3025
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
Language: English
Record Identifier: 99450165902621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Pathology

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