Arousal dissociates amygdala and hippocampal fear responses: Evidence from simultaneous fmri and skin conductance recording

L M Williams; M L Phillips; M J Brammer; D Skerrett; Jim Lagopoulos; C Rennie; H Bahramali; G Olivieri; A S David; A Peduto; E Gordon

doi:10.1006/nimg.2001.0904

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Arousal dissociates amygdala and hippocampal fear responses: Evidence from simultaneous fmri and skin conductance recording

Journal article

Peer reviewed

Arousal dissociates amygdala and hippocampal fear responses: Evidence from simultaneous fmri and skin conductance recording

L M Williams, M L Phillips, M J Brammer, D Skerrett, Jim Lagopoulos, C Rennie, H Bahramali, G Olivieri, A S David, A Peduto, …

NeuroImage, Vol.14(5), pp.1070-1079

2001

DOI: https://doi.org/10.1006/nimg.2001.0904

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Abstract

fMRI

amygdala

hippocampus

arousal

fear

facial emotion

The experience and appraisal of threat is essential to human and animal survival. Lesion evidence suggests that the subjective experience of fear relies upon amygdala-medial frontal activity (as well as autonomic arousal), whereas the factual context of threat stimuli depends upon hippocampal-lateral frontal activity. This amygdala-hippocampus dissociation has not previously been demonstrated in vivo. To explore this differentiation, we employed functional magnetic resonance imaging (fMRI) and simultaneous skin conductance response (SCR) measures of phasic arousal, while subjects viewed fearful versus neutral faces. fMRI activity was subaveraged according to whether or not the subject evoked an arousal SCR to each discrete face stimulus. The fMRI-with arousal and fMRI-without arousal data provided a distinct differentiation of amygdala and hippocampal networks. Amygdala-medial frontal activity was observed only with SCRs, whereas hippocampus-lateral frontal activity occurred only in the absence of SCRs. The findings provide direct evidence for a dissociation between human amygdala and hippocampus networks in the visceral experience versus declarative fact processing of fear. © 2001 Academic Press.

Details

Title: Arousal dissociates amygdala and hippocampal fear responses: Evidence from simultaneous fmri and skin conductance recording
Authors: L M Williams (Author) - University of Sydney
M L Phillips (Author) - University of Sydney
M J Brammer (Author) - University of Sydney
D Skerrett (Author) - University of Sydney
Jim Lagopoulos (Author) - University of Sydney
C Rennie (Author) - University of Sydney
H Bahramali (Author) - University of Sydney
G Olivieri (Author) - University of Sydney
A S David (Author) - University of Sydney
A Peduto (Author) - University of Sydney
E Gordon (Author) - University of Sydney
Publication details: NeuroImage, Vol.14(5), pp.1070-1079
Publisher: Elsevier BV
Date published: 2001
DOI: 10.1006/nimg.2001.0904
ISSN: 1053-8119
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99449293702621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Neuroimaging; Neurosciences; Radiology, Nuclear Medicine & Medical Imaging