Journal article
Apathy predicts rate of cognitive decline over 24 months in premanifest Huntington's disease
Psychological Medicine, Vol.51(8), pp.1338-1344
2021
PMID: 32063235
Abstract
Background: Cognitive impairment is a core feature of Huntington's disease (HD), however, the onset and rate of cognitive decline is highly variable. Apathy is the most common neuropsychiatric symptom of HD, and is associated with cognitive impairment. The aim of this study was to investigate apathy as a predictor of subsequent cognitive decline over 2 years in premanifest and early HD, using a prospective, longitudinal design. Methods: A total of 118 premanifest HD gene carriers, 111 early HD and 118 healthy control participants from the multi-centre TRACK-HD study were included. Apathy symptoms were assessed at baseline using the apathy severity rating from the Short Problem Behaviours Assessment. A composite of 12 outcome measures from nine cognitive tasks was used to assess cognitive function at baseline and after 24 months. Results: In the premanifest group, after controlling for age, depression and motor signs, more apathy symptoms predicted faster cognitive decline over 2 years. In contrast, in the early HD group, more motor signs, but not apathy, predicted faster subsequent cognitive decline. In the control group, only older age predicted cognitive decline. Conclusions: Our findings indicate that in premanifest HD, apathy is a harbinger for cognitive decline. In contrast, after motor onset, in early diagnosed HD, motor symptom severity more strongly predicts the rate of cognitive decline.
Details
- Title
- Apathy predicts rate of cognitive decline over 24 months in premanifest Huntington's disease
- Authors
- S. C. Andrews (Author) - Monash UniversityD. R. Langbehn (Author) - University of IowaD. Craufurd (Author) - University of ManchesterA. Durr (Author) - Université Sorbonne NouvelleB. R. Leavitt (Author) - University of British ColumbiaR. A. Roos (Author) - Leiden UniversityS. J. Tabrizi (Author) - University College LondonJ. C. Stout (Corresponding Author) - Monash UniversityTRACK-HD Investigators (Author)
- Publication details
- Psychological Medicine, Vol.51(8), pp.1338-1344
- Publisher
- Cambridge University Press
- DOI
- 10.1017/S0033291720000094
- ISSN
- 1469-8978
- PMID
- 32063235
- Organisation Unit
- Thompson Institute; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99659598002621
- Output Type
- Journal article
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- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Psychiatry
- Psychology
- Psychology, Clinical
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