Journal article
Apathy Associated With Impaired Recognition of Happy Facial Expressions in Huntington’s Disease
Journal of the International Neuropsychological Society, Vol.25(5), pp.453-461
2019
PMCID: PMC6542690
PMID: 30767839
Abstract
Objectives: Previous research has demonstrated an association between emotion recognition and apathy in several neurological conditions involving fronto-striatal pathology, including Parkinson’s disease and brain injury. In line with these findings, we aimed to determine whether apathetic participants with early Huntington’s disease (HD) were more impaired on an emotion recognition task compared to non-apathetic participants and healthy controls. Methods: We included 43 participants from the TRACK-HD study who reported apathy on the Problem Behaviours Assessment – short version (PBA-S), 67 participants who reported no apathy, and 107 controls matched for age, sex, and level of education. During their baseline TRACK-HD visit, participants completed a battery of cognitive and psychological tests including an emotion recognition task, the Hospital Depression and Anxiety Scale (HADS) and were assessed on the PBA-S. Results: Compared to the non-apathetic group and the control group, the apathetic group were impaired on the recognition of happy facial expressions, after controlling for depression symptomology on the HADS and general disease progression (Unified Huntington’s Disease Rating Scale total motor score). This was despite no difference between the apathetic and non-apathetic group on overall cognitive functioning assessed by a cognitive composite score. Conclusions: Impairment of the recognition of happy expressions may be part of the clinical picture of apathy in HD. While shared reliance on frontostriatal pathways may broadly explain associations between emotion recognition and apathy found across several patient groups, further work is needed to determine what relationships exist between recognition of specific emotions, distinct subtypes of apathy and underlying neuropathology. (JINS, 2019, 25, 453–461)
Details
- Title
- Apathy Associated With Impaired Recognition of Happy Facial Expressions in Huntington’s Disease
- Authors
- Katherine Osborne-Crowley (Corresponding Author) - University College LondonSophie C Andrews (Author) - Monash UniversityIzelle Labuschagne (Author) - Australian Catholic UniversityAkshay Nair (Author) - University College LondonRachael Scahill (Author) - University College LondonDavid Craufurd (Author) - University of ManchesterSarah J Tabrizi (Author) - University College LondonJulie C Stout (Author) - Monash UniversityTRACK-HD Investigators (Author)
- Publication details
- Journal of the International Neuropsychological Society, Vol.25(5), pp.453-461
- Publisher
- Cambridge University Press
- DOI
- 10.1017/S1355617718001224
- ISSN
- 1469-7661
- PMID
- 30767839; PMC6542690
- Organisation Unit
- Thompson Institute; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99659597302621
- Output Type
- Journal article
Metrics
15 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- Psychiatry
- Psychology
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites