Antioxidant and anti-inflammatory activities of selected medicinal plants containing phenolic and flavonoid compounds

L Zhang; A S Ravipati; S R Koyyalamudi; S C Jeong; N Reddy; P T Smith; John R Bartlett; K Shanmugam; G Münch; M J Wu

doi:10.1021/jf203146e

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Antioxidant and anti-inflammatory activities of selected medicinal plants containing phenolic and flavonoid compounds

Journal article

Peer reviewed

Antioxidant and anti-inflammatory activities of selected medicinal plants containing phenolic and flavonoid compounds

L Zhang, A S Ravipati, S R Koyyalamudi, S C Jeong, N Reddy, P T Smith, John R Bartlett, K Shanmugam, G Münch and M J Wu

Journal of Agricultural and Food Chemistry, Vol.59(23), pp.12361-12367

2011

DOI: https://doi.org/10.1021/jf203146e

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Abstract

medicinal plants

antioxidant activity

anti-inflammatory

phenolics

flavonoids

The antioxidant, anti-inflammatory, and cytotoxic activities of water and ethanol extracts of 14 Chinese medicinal plants were investigated and also their total phenolics and flavonoid contents measured. The antioxidant activity was evaluated in a biological assay using Saccharomyces cerevisiae, whereas the radical scavenging activity was measured using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Total phenolics and flavonoid contents were estimated by Folin-Ciocalteu and aluminum chloride methods, respectively. The anti-inflammatory activities of the plant extracts were determined by measuring the inhibition of production of nitric oxide (NO) and TNF-α in LPS and IFN-γ activated RAW 264.7 macrophages. Their cytotoxic activities against macrophages were determined by Alamar Blue assay. Four plants, namely, Scutellaria baicalensis, Taxillus chinensis, Rheum officinale, and Sophora japonica, showed significant antioxidant activity in both yeast model and also free radical scavenging methods. The ethanol extract of S. japonica showed highest levels of phenolics and flavonoids (91.33 GAE mg/g and 151.86 QE mg/g, respectively). A positive linear correlation between antioxidant activity and the total phenolics and flavonoid contents indicates that these compounds are likely to be the main antioxidants contributing to the observed activities. Five plant extracts (S. baicalensis, T. chinensis, S. japonica, Mahonia fortunei, and Sophora flavescens) exhibited significant anti-inflammatory activity by in vitro inhibition of the production of NO and TNF-α with low IC 50 values. These findings suggest that some of the medicinal herbs studied in this paper are good sources of antioxidants.

Details

Title: Antioxidant and anti-inflammatory activities of selected medicinal plants containing phenolic and flavonoid compounds
Authors: L Zhang (Author) - University of Western Sydney
A S Ravipati (Author) - University of Western Sydney
S R Koyyalamudi (Author) - University of Western Sydney
S C Jeong (Author) - University of Western Sydney
N Reddy (Author) - University of Western Sydney
P T Smith (Author) - University of Western Sydney
John R Bartlett (Author) - University of Western Sydney
K Shanmugam (Author) - University of Western Sydney
G Münch (Author) - University of Western Sydney
M J Wu (Author) - University of Western Sydney
Publication details: Journal of Agricultural and Food Chemistry, Vol.59(23), pp.12361-12367
Publisher: American Chemical Society
Date published: 2011
DOI: 10.1021/jf203146e
ISSN: 0021-8561
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99448970402621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology

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